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I Lalezari

Explore the profile of I Lalezari including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 43
Citations 106
Followers 0
Related Specialties
Pharmacology
Pharmacy
Chemistry
Top 10 Co-Authors
A Shafiee
P Lalezari
S Yazdany
S Rahbar
H Golgolab
F Abtahi
M A KHOYI
F Afghahi
F Ghabgharan
W A Franklin
Published In
J Pharm Sci
J Med Chem
Lloydia
Proc Natl Acad Sci U S A
Radiat Res
Affiliations
Soon will be listed here.
Recent Articles
1.
Effects of LF-14, THA and physostigmine in rat hippocampus and cerebral cortex
Potter P, Nitta S, Chaudhry I, Lalezari I, Goldiner P, Foldes F
Neurochem Int . 2010 May; 14(4):433-8. PMID: 20504446
The effects of physostigmine, tetrahydroaminoacridine (THA) and LF-14 [3,3-dimethyl-1(4- amino-3-pyridyl)urea], a 3,4-diaminopyridine derivative, were compared on inhibition of acetyl- cholinesterase (AChE) activity, and release of [(3)H]acetylcholine (ACh) from rat brain...
2.
Novel inhibitors of advanced glycation endproducts (part II)
Rahbar S, Yerneni K, Scott S, Gonzales N, Lalezari I
Mol Cell Biol Res Commun . 2000 Oct; 3(6):360-6. PMID: 11032758
Enhanced formation and accumulation of advanced glycation endproducts (AGEs), have been implicated as a major pathogenesis process leading to diabetic complications, normal aging, atherosclerosis, and Alzheimer's Disease. Several potential drug...
3.
Novel inhibitors of advanced glycation endproducts
Rahbar S, Kumar Yernini K, Scott S, Gonzales N, Lalezari I
Biochem Biophys Res Commun . 1999 Sep; 262(3):651-6. PMID: 10471380
Enhanced formation and accumulation of advanced glycation endproducts (AGE's) have been proposed to play a major role in the pathogenesis of diabetic complications, aging, atherosclerosis, and Alzheimer disease leading to...
4.
Evaluation of 2-(3-aminobenzamido)-2-deoxy-D-glucose as a radiosensitizer
Winer S, BASES R, Lalezari I, Brownlee M, Franklin W
Radiology . 1995 Jul; 196(1):267-9. PMID: 7784578
Purpose: 3-Aminobenzamide (3-AB), an inhibitor of poly(adenosine diphosphate [ADP]-ribose) synthetase, functions as a radiosensitizer in several human tumor cell lines. 2-(3-AB)-2-deoxy-D-glucose (3-AB-G) was designed to increase preferentially the intracellular concentration...
5.
Excision of sugar-phosphate products at apurinic/apyrimidinic sites by DNA deoxyribophosphodiesterase of Escherichia coli
Sandigursky M, Lalezari I, Franklin W
Radiat Res . 1992 Sep; 131(3):332-7. PMID: 1332111
It has been shown previously that the DNA deoxyribophosphodiesterase (dRpase) activity of Escherichia coli excises 2-deoxyribose 5-phosphate moieties at apurinic/apyrimidinic (AP) sites in DNA following cleavage of the DNA at...
6.
New effectors of human hemoglobin: structure and function
Lalezari I, Lalezari P, Poyart C, Marden M, Kister J, Bohn B, et al.
Biochemistry . 1990 Feb; 29(6):1515-23. PMID: 2334712
We describe the actions of two new allosteric effectors of hemoglobin, 2-[4-(3,5-dichlorophenylureido)phenoxy]-2-methylpropionic acid (L35) and 2-[4-(3,4,5-trichlorophenylureido)phenoxy]-2-methylpropionic acid (L345). Each of them binds to two pairs of symmetry-related sites in the...
7.
Synthesis and investigation of effects of 2-[4- [[(arylamino)carbonyl]amino]phenoxy]-2-methylpropionic acids on the affinity of hemoglobin for oxygen: structure-activity relationships
Lalezari I, Lalezari P
J Med Chem . 1989 Oct; 32(10):2352-7. PMID: 2795607
A series of 2-[4-[[[(substituted-phenyl)amino]carbonyl]amino]phenoxy]-2- methylpropionic acids and other substituted phenoxyacetic acids were synthesized and tested for their ability to reduce the affinity of hemoglobin for oxygen. 2-[4-[[[(3,4,5-trichlorophenyl)amino]carbonyl]amino]phenoxy]-2- methylpropionic acid was...
8.
LR16, a compound with potent effects on the oxygen affinity of hemoglobin, on blood cholesterol, and on low density lipoprotein
Lalezari I, Rahbar S, Lalezari P, FERMI G, Perutz M
Proc Natl Acad Sci U S A . 1988 Aug; 85(16):6117-21. PMID: 3413080
2-[4-(3,4-Dichlorophenylureido)phenoxy]-2-methylpropionic acid, LR16, combines with two symmetrically related sites in the central cavity of deoxyhemoglobin, 20 A away from the binding site of 2,3-bisphosphoglycerate, and acts as an allosteric effector...
9.
Synthesis and antineoplastic activity of 5-aryl-2,3-dihydropyrrolo[2,1-b]thiazole-6,7-dimethanol 6,7-bis(isopropylcarbamates)
Lalezari I, Schwartz E
J Med Chem . 1988 Jul; 31(7):1427-9. PMID: 3164410
A series of 1-thia analogues of the pyrrolizine bis(carbamate) 9 (NSC-278214), namely 5-aryl-2,3-dihydropyrrolo-[2,1-b]thiazole-6,7-dimethanol 6,7-bis(isopropylcarbamates) (7a-d), were prepared by multistep syntheses from the proline analogue thiazolidine-2-carboxylic acid. The compounds were tested...
10.
Effect of mono- and diaminopyridines on release of [3H]norepinephrine from isolated guinea-pig atrium
Sugimori T, Nagashima H, Vizi E, Harsing Jr L, Chaudhry I, Lalezari I, et al.
Neuropharmacology . 1987 Jun; 26(6):621-6. PMID: 3037424
Neurochemical evidence has been obtained that 4-aminopyridine, 3,4-diaminopyridine and 3,3-dimethyl-1-(4-amino-3-pyridyl)urea HBr (LF-14), concentration-dependently enhanced the stimulation-evoked release of [3H]norepinephrine ([3H]NE) from isolated guinea-pig atrium. The effects of aminopyridines, compounds known...