Alpha 2.0
Login Register
» Authors » I J Harmer

I J Harmer

Explore the profile of I J Harmer including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 23
Followers 0
Related Specialties
Allergy & Immunology
Rheumatology
Pathology
Top 10 Co-Authors
C G Mackworth-Young
R A Mageed
M Bruggemann
A Rankin
N Jennings
S P Moyes
D Samuel
C Mackworth-Young
M J Walport
P A Smethurst
Published In
Clin Exp Immunol
J Immunol Methods
Lupus
Arthritis Rheum
Immunology
Affiliations
Soon will be listed here.
Recent Articles
1.
Definition of novel GP6 polymorphisms and major difference in haplotype frequencies between populations by a combination of in-depth exon resequencing and genotyping with tag single nucleotide polymorphisms
Watkins N, OConnor M, Rankin A, Jennings N, Wilson E, Harmer I, et al.
J Thromb Haemost . 2006 May; 4(6):1197-205. PMID: 16706959
Background: Common genetic variants of cell surface receptors contribute to differences in functional responses and disease susceptibility. We have previously shown that single nucleotide polymorphisms (SNPs) in platelet glycoprotein VI...
2.
The role of antigen in the selection of the human V3-23 immunoglobulin heavy chain variable region gene
Mackworth-Young C, Harmer I, Mageed R
Clin Exp Immunol . 2003 Nov; 134(3):420-5. PMID: 14632746
The immune system mounts antibody responses using few of the available immunoglobulin variable region (IgV) genes with some, such as the V3-23 heavy chain gene, regularly over-represented in responses to...
3.
Rearrangement of the human heavy chain variable region gene V3-23 in transgenic mice generates antibodies reactive with a range of antigens on the basis of VHCDR3 and residues intrinsic to the heavy chain variable region
Mageed R, Harmer I, Wynn S, Moyes S, Maziak B, Bruggemann M, et al.
Clin Exp Immunol . 2001 Feb; 123(1):1-8. PMID: 11167990
To formulate a 'logic' for how a single immunoglobulin variable region gene generates antibodies with different antigen specificity and polyreactivity, we analysed chimeric antibodies produced in transgenic mice carrying the...
4.
The BH1 idiotype defines a population of anticardiolipin antibodies closely associated with the antiphospholipid syndrome
Mason A, Harmer I, Mageed R, Mackworth-Young C
Lupus . 1999 May; 8(3):234-9. PMID: 10342717
Background: A human IgM monoclonal anticardiolipin antibody - BH1 - has previously been described, which has characteristics typical of antiphospholipid antibodies in the serum of patients with antiphospholipid syndrome (APS)....
5.
Chimaeric monoclonal antibodies encoded by the human VH26 gene from naïve transgenic mice display a wide range of antigen-binding specificities
Harmer I, Mageed R, Kaminski A, Charles P, Bruggemann M, Mackworth-Young C
Immunology . 1996 Jun; 88(2):174-82. PMID: 8690448
To elucidate the molecular basis for the ability of antibodies encoded by the human VH26 heavy-chain variable region gene to react with diverse antigens, we have generated 34 hybridomas secreting...
6.
A human monoclonal antiphospholipid antibody that is representative of serum antibodies and is germline encoded
Harmer I, Loizou S, Thompson K, So A, Walport M, Mackworth-Young C
Arthritis Rheum . 1995 Aug; 38(8):1068-76. PMID: 7639802
Objective: To investigate the origins of antiphospholipid antibodies associated with thrombosis and other disorders that are found in patients with systemic lupus erythematosus and primary antiphospholipid syndrome (APS). Methods: Characterization,...
7.
The FITC-anti-FITC system is a sensitive alternative to biotin-streptavidin in ELISA
Harmer I, Samuel D
J Immunol Methods . 1989 Aug; 122(1):115-21. PMID: 2503563
In a model ELISA system alkaline phosphatase (AP) absorbed onto microtitre wells was employed as the target antigen. The antigen was then reacted with a monoclonal antibody to AP either...