I Hishinuma
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Explore the profile of I Hishinuma including associated specialties, affiliations and a list of published articles.
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14
Citations
116
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Recent Articles
1.
Yoshimura H, Nagai M, Hibi S, Kikuchi K, Abe S, Hida T, et al.
J Med Chem
. 1995 Aug;
38(16):3163-73.
PMID: 7636879
A new series of heterocyclic ring-containing benzoic acids was prepared, and the binding affinity and antagonism of its members against all-trans-retinoic acid were evaluated by in vitro assay systems using...
2.
Miyamoto K, Nagakawa J, Nagaoka N, Hishinuma I, Nagaoka J, Yamanaka T, et al.
Nihon Yakurigaku Zasshi
. 1994 Oct;
104(4):337-45.
PMID: 7959424
We studied the effect of E3123 on pancreatic injury induced in the isolated, perfused pancreas or in a pancreatic slice. Exposure of the isolated, perfused rat pancreas to trypsin-taurocholate or...
3.
Nagakawa J, Hirota K, Hishinuma I, Miyamoto K, Sonoda J, Yamanaka T, et al.
J Pharmacol Exp Ther
. 1993 Jan;
264(1):496-500.
PMID: 8423547
The effect of E3330 ((2E)-3-[5-(2,3-dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2-++ +propenoic acid), a novel quinone derivative, was studied in the galactosamine-induced hepatitis model in F344 rats, in which endogenous endotoxin is believed to play a...
4.
Nagakawa J, Hishinuma I, Hirota K, Miyamoto K, Yamanaka T, Yamatsu I, et al.
Eur J Pharmacol
. 1992 Dec;
229(1):63-7.
PMID: 1335420
Oral pretreatment with E3330, a novel quinone derivative, attenuated liver injury induced with tumor necrosis factor-alpha in galactosamine-sensitized mice. Tumor necrosis factor-alpha is known to induce inflammatory mediators such as...
5.
Miyamoto K, Nagakawa J, Hishinuma I, Hirota K, Yasuda M, Yamanaka T, et al.
Agents Actions
. 1992 Nov;
37(3-4):297-304.
PMID: 1284192
E3330 [(2E)-3-[5-(2,3-dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2- propenoic acid], a novel synthesized hepatoprotective compound, has suppressive effects on tumor necrosis factor-alpha (TNF-alpha) generation from monocytes/macrophages in vitro. E3330 (1-100 microM) reduced lipopolysaccharide (LPS, 10 mg/ml...
6.
Nagakawa J, Hishinuma I, Miyamoto K, Hirota K, Abe S, Yamanaka T, et al.
J Pharmacol Exp Ther
. 1992 Jul;
262(1):145-50.
PMID: 1625194
E3330 [(2E)-3-[5-(2,3-dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2- propenoic acid] is a newly synthesized hepatoprotective quinone derivative. We examined the protective effects and possible mechanism of action of E3330 in three different endotoxin (lipopolysaccharide)-induced murine hepatitis...
7.
Nagakawa J, Hishinuma I, Hirota K, Miyamoto K, Yasuda M, Yamanaka T, et al.
Immunopharmacol Immunotoxicol
. 1991 Jan;
13(4):485-98.
PMID: 1774433
The possible involvement of interleukin-1 alpha (IL-1 alpha) in the pathogenesis of murine hepatitis model induced with galactosamine and lipopolysaccharide (LPS) was investigated. The injection of 10 ng/mouse of LPS...
8.
Hishinuma I, Nagakawa J, Hirota K, Miyamoto K, Tsukidate K, Yamanaka T, et al.
Hepatology
. 1990 Nov;
12(5):1187-91.
PMID: 2227817
Intravenous injection of lipopolysaccharide and D-galactosamine, at doses of 0.2 micrograms/kg and 800 mg/kg, respectively, elicited massive hepatic necrosis within 24 hr in C3H/HeN mice. The plasma L-alanine aminotransferase (ALT,...
9.
Nagakawa J, Hishinuma I, Hirota K, Miyamoto K, Yamanaka T, Tsukidate K, et al.
Gastroenterology
. 1990 Sep;
99(3):758-65.
PMID: 2379780
The possible involvement of tumor necrosis factor-alpha in the pathogenesis of an experimentally induced hepatitis was investigated. Balb/c mice were primed with Propionibacterium acnes to induce the infiltration of mononuclear...
10.
Miyamoto K, Hishinuma I, Nagakawa J, Nagaoka N, Yamanaka T, Wakabayashi T
Nihon Yakurigaku Zasshi
. 1988 May;
91(5):285-93.
PMID: 3410375
4-(2-Succinimidoethylthio) phenyl 4-guanidinobenzoate (E-3123) potently inhibited trypsin, plasmin and thrombin with IC50 values of 3.9 x 10(-8) M, 9.5 x 10(-7) M and 1.9 x 10(-6) M, respectively. Experimental acute...