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Hyun Gyu Lim

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Articles 39
Citations 394
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Recent Articles
1.
Lim H, Gao Y, Rychel K, Lamoureux C, Lou X, Palsson B
mSystems . 2024 Dec; 10(1):e0131524. PMID: 39714213
Importance: Nutrient limitations are critical environmental perturbations in bacterial physiology. Despite its importance, a detailed understanding of how bacterial transcriptomes are adjusted has been limited. By utilizing independent component analysis...
2.
Woo S, Han Y, Lee H, Baek D, Noh M, Han S, et al.
Metab Eng . 2024 Nov; 86:300-307. PMID: 39489215
Raffinose, a trisaccharide abundantly found in soybeans, is a potential alternative carbon source for biorefineries. Nevertheless, residual intermediate di- or monosaccharides and low catabolic efficiency limit raffinose use through conventional...
3.
Rodionova I, Lim H, Gao Y, Rodionov D, Hutchison Y, Szubin R, et al.
Commun Biol . 2024 Sep; 7(1):1160. PMID: 39289465
Hydrogen sulfide (HS), mainly produced from L-cysteine (Cys), renders bacteria highly resistant to oxidative stress and potentially increases antimicrobial resistance (AMR). CyuR is a Cys-dependent transcription regulator, responsible for the...
4.
Moon J, Woo S, Shin H, Lee H, Jung G, Lim H
J Agric Food Chem . 2024 Jul; 72(30):16860-16866. PMID: 39031782
Itaconate is a promising platform chemical with broad applicability, including the synthesis of poly(methyl methacrylate). Most studies on microbial itaconate production entail the use of crop-based feedstock, which imposes constraints...
5.
Kim H, Noh M, White E, Kandefer M, Wright A, Datta D, et al.
Nat Commun . 2024 Apr; 15(1):3338. PMID: 38688899
The field of hybrid engineered living materials seeks to pair living organisms with synthetic materials to generate biocomposite materials with augmented function since living systems can provide highly-programmable and complex...
6.
Borchert A, Bleem A, Lim H, Rychel K, Dooley K, Kellermyer Z, et al.
mSystems . 2024 Feb; 9(3):e0094223. PMID: 38323821
Importance: This study demonstrates a rapid, automated approach for elucidating functional modules within complex genetic networks. While randomly barcoded transposon insertion sequencing data were used as a proof of concept,...
7.
Lee H, Woo S, Baek D, Min M, Jung G, Lim H
Bioresour Technol . 2024 Jan; 394:130304. PMID: 38211713
Brown macroalgae is a promising feedstock for biorefinery owing to its high biomass productivity and contents of carbohydrates such as alginate and mannitol. However, the limited availability of microbial platforms...
8.
Rodionova I, Lim H, Rodionov D, Hutchison Y, Dalldorf C, Gao Y, et al.
bioRxiv . 2023 Jun; PMID: 37292663
Hydrogen sulfide (H S), mainly produced from L-cysteine (Cys), renders bacteria highly resistant to oxidative stress. This mitigation of oxidative stress was suggested to be an important survival mechanism to...
9.
Hirose Y, Poudel S, Sastry A, Rychel K, Lamoureux C, Szubin R, et al.
mSystems . 2023 Jun; 8(3):e0024723. PMID: 37278526
can cause a wide variety of acute infections throughout the body of its human host. An underlying transcriptional regulatory network (TRN) is responsible for altering the physiological state of the...
10.
Lennen R, Lim H, Jensen K, Mohammed E, Phaneuf P, Noh M, et al.
Metab Eng . 2023 Feb; 76:179-192. PMID: 36738854
Although strain tolerance to high product concentrations is a barrier to the economically viable biomanufacturing of industrial chemicals, chemical tolerance mechanisms are often unknown. To reveal tolerance mechanisms, an automated...