Hui Sun Leong
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Explore the profile of Hui Sun Leong including associated specialties, affiliations and a list of published articles.
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34
Citations
1445
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Recent Articles
1.
Leong H, Zhang T, Corrigan A, Serrano A, Kunzel U, Mullooly N, et al.
PLoS One
. 2024 Sep;
19(9):e0310433.
PMID: 39264962
Hit screening, which involves the identification of compounds or targets capable of modulating disease-relevant processes, is an important step in drug discovery. Some assays, such as image-based high-content screenings, produce...
2.
Toh S, Leong H, Chong F, Rodrigues-Junior D, Ren M, Kwang X, et al.
Dev Cell
. 2024 Aug;
59(16):2189-2202.e8.
PMID: 39089249
Targeting wild-type epidermal growth factor receptor (EGFR) using tyrosine kinase inhibitors (TKIs) never achieved its purported success in cancers such as head and neck squamous cell carcinoma, which are largely...
3.
Quah H, Cao E, Suteja L, Li C, Leong H, Chong F, et al.
Nat Commun
. 2023 Mar;
14(1):1680.
PMID: 36973261
Profiling tumors at single-cell resolution provides an opportunity to understand complexities underpinning lymph-node metastases in head and neck squamous-cell carcinoma. Single-cell RNAseq (scRNAseq) analysis of cancer-cell trajectories identifies a subpopulation...
4.
Shi L, Magee P, Fassan M, Sahoo S, Leong H, Lee D, et al.
Nat Commun
. 2021 Apr;
12(1):2038.
PMID: 33795683
Wild-type KRAS (KRAS) amplification has been shown to be a secondary means of KRAS activation in cancer and associated with poor survival. Nevertheless, the precise role of KRAS overexpression in...
5.
Monteverde T, Sahoo S, La Montagna M, Magee P, Shi L, Lee D, et al.
Cancer Res
. 2021 Jan;
81(7):1719-1731.
PMID: 33472893
Chromosomal instability (CIN) is a driver of clonal diversification and intratumor heterogeneity, providing genetic diversity that contributes to tumor progression. It is estimated that approximately 80% of solid cancers, including...
6.
Lek S, Li K, Tan Q, Shannon N, Ng W, Hendrikson J, et al.
Oral Oncol
. 2020 Oct;
111:105035.
PMID: 33091845
Objectives: We have previously identified and validated a panel of molecular prognostic markers (ATP13A3, SSR3, and ANO1) for Head and Neck Squamous Cell Carcinoma (HNSCC). The aim of this study...
7.
Mohan S, Foy V, Ayub M, Leong H, Schofield P, Sahoo S, et al.
J Thorac Oncol
. 2019 Oct;
15(2):216-230.
PMID: 31629061
Introduction: SCLC accounts for approximately 250,000 deaths worldwide each year. Acquisition of adequate tumor biopsy samples is challenging, and liquid biopsies present an alternative option for patient stratification and response...
8.
Rodrigues-Junior D, Tan S, Lim S, Leong H, Melendez M, Ramos C, et al.
Carcinogenesis
. 2019 Aug;
40(12):1452-1461.
PMID: 31436806
Management of locally advanced head and neck squamous cell carcinoma (HNSCC) requires a multi-prong approach comprising surgery, radiation and/or chemotherapy, yet outcomes are limited. This is largely due to a...
9.
Mohan S, Ayub M, Rothwell D, Gulati S, Kilerci B, Hollebecque A, et al.
Sci Rep
. 2019 Aug;
9(1):11610.
PMID: 31406261
Serial biopsy of pancreatic ductal adenocarcinoma (PDAC), to chart tumour evolution presents a significant challenge. We examined the utility of circulating free DNA (cfDNA) as a minimally invasive approach across...
10.
Parry M, Srivastava S, Ali A, Cannistraci A, Antonello J, Barros-Silva J, et al.
Eur Urol Oncol
. 2019 Apr;
2(1):1-11.
PMID: 30929837
Background: The prostate cancer (PCa) diagnostic pathway is undergoing a radical change with the introduction of multiparametric magnetic resonance imaging (mpMRI), genomic testing, and different prostate biopsy techniques. It has...