Hui-Chun Lu
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Explore the profile of Hui-Chun Lu including associated specialties, affiliations and a list of published articles.
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14
Citations
341
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Recent Articles
1.
Fadaili Y, Lu H, Lee H, Ryazapova A, Stern C
Development
. 2025 Jan;
152(2).
PMID: 39804118
In chick embryos before primitive streak formation, the outermost extra-embryonic region, known as the area opaca (AO), was generally thought to act only by providing nutrients and mechanical support to...
2.
Lee H, Oliveira N, Hastings C, Baillie-Benson P, Moverley A, Lu H, et al.
Nat Commun
. 2024 Feb;
15(1):1463.
PMID: 38368410
Many amniote vertebrate species including humans can form identical twins from a single embryo, but this only occurs rarely. It has been suggested that the primitive-streak-forming embryonic region emits signals...
3.
Trevers K, Lu H, Yang Y, Thiery A, Strobl A, Anderson C, et al.
Elife
. 2023 Mar;
12.
PMID: 36867045
During early vertebrate development, signals from a special region of the embryo, the organizer, can redirect the fate of non-neural ectoderm cells to form a complete, patterned nervous system. This...
4.
Solovieva T, Lu H, Moverley A, Plachta N, Stern C
Proc Natl Acad Sci U S A
. 2022 Feb;
119(5).
PMID: 35101917
In warm-blooded vertebrate embryos (mammals and birds), the axial tissues of the body form from a growth zone at the tail end, Hensen's node, which generates neural, mesodermal, and endodermal...
5.
Lee H, Lu H, Turmaine M, Oliveira N, Yang Y, De Almeida I, et al.
Open Biol
. 2020 Feb;
10(2):190299.
PMID: 32102607
The early stages of development of the chick embryo, leading to primitive streak formation (the start of gastrulation), have received renewed attention recently, especially for studies of the mechanisms of...
6.
Anderson C, Hill B, Lu H, Moverley A, Yang Y, Oliveira N, et al.
Dev Biol
. 2019 Jul;
456(1):40-46.
PMID: 31283921
We present a detailed analysis of gene expression in the 2-day (HH12) embryonic chick heart. RNA-seq of 13 micro-dissected regions reveals regionalised expression of 15,570 genes. Of these, 132 were...
7.
Margreitter C, Lu H, Townsend C, Stewart A, Dunn-Walters D, Fraternali F
Nucleic Acids Res
. 2018 Apr;
46(W1):W264-W270.
PMID: 29668996
Antibody repertoire analysis by high throughput sequencing is now widely used, but a persisting challenge is enabling immunologists to explore their data to discover discriminating repertoire features for their own...
8.
Lu H, Herrera Braga J, Fraternali F
Bioinformatics
. 2016 May;
32(16):2534-6.
PMID: 27153707
Unlabelled: We present a practical computational pipeline to readily perform data analyses of protein-protein interaction networks by using genetic and functional information mapped onto protein structures. We provide a 3D...
9.
Lu H, Chung S, Fornili A, Fraternali F
Front Mol Biosci
. 2015 Sep;
2:47.
PMID: 26322316
Integration of protein structural information with human genetic variation and pathogenic mutations is essential to understand molecular mechanisms associated with the effects of polymorphisms on protein interactions and cellular processes....
10.
AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 trafficking
Setta-Kaffetzi N, Simpson M, Navarini A, Patel V, Lu H, Allen M, et al.
Am J Hum Genet
. 2014 May;
94(5):790-7.
PMID: 24791904
Adaptor protein complex 1 (AP-1) is an evolutionary conserved heterotetramer that promotes vesicular trafficking between the trans-Golgi network and the endosomes. The knockout of most murine AP-1 complex subunits is...