Hugo Stocker
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Explore the profile of Hugo Stocker including associated specialties, affiliations and a list of published articles.
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44
Citations
2427
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Recent Articles
1.
Mukherjee A, Huang Y, Elgeti J, Oh S, Abreu J, Neliat A, et al.
bioRxiv
. 2023 Nov;
PMID: 37961564
Mechanical forces have been shown to influence cellular decisions to grow, die, or differentiate, through largely mysterious mechanisms. Separately, changes in resting membrane potential have been observed in development, differentiation,...
2.
Parniewska M, Stocker H
Int J Mol Sci
. 2020 Jul;
21(12).
PMID: 32599686
The Target of Rapamycin complex 1 (TORC1) is an evolutionarily conserved kinase complex coordinating cellular growth with nutritional conditions and growth factor signaling, and its activity is elevated in many...
3.
Gupta A, Stocker H
Elife
. 2020 Jun;
9.
PMID: 32525804
The transcription factor FoxO has been shown to block proliferation and progression in mTORC1-driven tumorigenesis but the picture of the relevant FoxO target genes remains incomplete. Here, we employed RNA-seq...
4.
Gupta A, Stocker H
PLoS One
. 2020 Feb;
15(2):e0228995.
PMID: 32059043
Genetically encoded pH indicators (GEpHI) have emerged as important tools for investigating intracellular pH (pHi) dynamics in Drosophila. However, most of the indicators are based on the Gal4/UAS binary expression...
5.
Nowak K, Gupta A, Stocker H
PLoS Genet
. 2018 Apr;
14(4):e1007347.
PMID: 29677182
TORC1, a central regulator of cell survival, growth, and metabolism, is activated in a variety of cancers. Loss of the tumor suppressors PTEN and Tsc1/2 results in hyperactivation of TORC1....
6.
Stocker H
Dev Cell
. 2017 Aug;
42(4):311-313.
PMID: 28829940
TORC1 is arguably the best-studied regulator of cellular growth in eukaryotes. However, its activity has not been assessed in vivo in developing multicellular organisms. Two studies in this issue of...
7.
Lujan E, Bornemann D, Rottig C, Bayless B, Stocker H, Hafen E, et al.
Genesis
. 2016 Sep;
54(11):573-581.
PMID: 27636555
The FLP/FRT system permits rapid phenotypic screening of homozygous lethal mutations in the context of a viable mosaic fly. Combining this system with ovo dominant female-sterile transgenes enables efficient production...
8.
Nie Y, Li Q, Amcheslavsky A, Duhart J, Veraksa A, Stocker H, et al.
Stem Cell Rev Rep
. 2015 Sep;
11(6):813-25.
PMID: 26323255
The Drosophila adult midgut contains intestinal stem cells that support homeostasis and repair. We show here that the leucine zipper protein Bunched and the adaptor protein Madm are novel regulators...
9.
Jevtov I, Zacharogianni M, van Oorschot M, van Zadelhoff G, Aguilera-Gomez A, Vuillez I, et al.
J Cell Sci
. 2015 Jun;
128(14):2497-508.
PMID: 26054799
The kinase TOR is found in two complexes, TORC1, which is involved in growth control, and TORC2, whose roles are less well defined. Here, we asked whether TORC2 has a...
10.
Stocker H
Dev Cell
. 2015 May;
33(3):245-6.
PMID: 25942621
Reduced activity of the growth-regulating TOR complex 1 induces transcription of many genes. In this issue of Developmental Cell, Tiebe et al. (2015) identify a transcriptional regulator complex repressed by...