Hugo Lee
Overview
Explore the profile of Hugo Lee including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
13
Citations
165
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Lee H, Thompson P, Engin F
STAR Protoc
. 2024 Mar;
5(1):102923.
PMID: 38427571
A subpopulation of pancreatic beta cells becomes senescent during type 1 diabetes (T1D) progression, and removal of these populations protects against T1D in mice. Here, we present a protocol to...
2.
Lee H, Sahin G, Chen C, Sonthalia S, Canas S, Oktay H, et al.
Cell Metab
. 2023 Nov;
35(12):2200-2215.e9.
PMID: 37949065
During the progression of type 1 diabetes (T1D), β cells are exposed to significant stress and, therefore, require adaptive responses to survive. The adaptive mechanisms that can preserve β cell...
3.
Hurley L, Lee H, Wade G, Simcox J, Engin F
Front Endocrinol (Lausanne)
. 2023 May;
14:1170461.
PMID: 37124760
Chronic elevation of sphingolipids contributes to β-cell failure. ORMDL3 has been identified as a key regulator of sphingolipid homeostasis, however, its function in pancreatic β-cell pathophysiology remains unclear. Here, we...
4.
Hurley L, Lee H, Wade G, Simcox J, Engin F
bioRxiv
. 2023 Feb;
PMID: 36798417
Chronic elevation of sphingolipids contributes to β-cell failure. ORMDL3 has been identified as a key regulator of sphingolipid homeostasis, however, its function in pancreatic β-cell pathophysiology remains unclear. Here, we...
5.
Chen C, Guan B, Alzahrani M, Gao Z, Gao L, Bracey S, et al.
Nat Commun
. 2022 Aug;
13(1):4621.
PMID: 35941159
Pancreatic β-cells are prone to endoplasmic reticulum (ER) stress due to their role in insulin secretion. They require sustainable and efficient adaptive stress responses to cope with this stress. Whether...
6.
Wong W, Thorat V, Joglekar M, Dong C, Lee H, Chew Y, et al.
Front Endocrinol (Lausanne)
. 2022 Apr;
13:853863.
PMID: 35399953
Machine learning (ML)-workflows enable unprejudiced/robust evaluation of complex datasets. Here, we analyzed over 490,000,000 data points to compare 10 different ML-workflows in a large (N=11,652) training dataset of human pancreatic...
7.
Sahin G, Lee H, Engin F
Mol Metab
. 2021 Nov;
54:101365.
PMID: 34728341
Background: Pancreatic β-cells are the insulin factory of an organism with a mission to regulate glucose homeostasis in the body. Due to their high secretory activity, β-cells rely on a...
8.
Lee H, Engin F
STAR Protoc
. 2020 Dec;
1(3):100144.
PMID: 33377038
Pancreatic islets consist of several cell types, including alpha, beta, delta, epsilon, and PP cells. Due to cellular heterogeneity, it is challenging to interpret whole-islet transcriptome data. Single-cell transcriptomics offers...
9.
Lee H, Fenske R, Akcan T, Domask E, Davis D, Kimple M, et al.
iScience
. 2020 Jul;
23(7):101324.
PMID: 32659722
The orosomucoid-like (Ormdl) proteins play a critical role in sphingolipid homeostasis, inflammation, and ER stress, all of which are associated with obesity and βcell dysfunction. However, their roles in β...
10.
Lee H, Lee Y, Harenda Q, Pietrzak S, Oktay H, Schreiber S, et al.
Cell Metab
. 2020 Mar;
31(4):822-836.e5.
PMID: 32220307
Immune-mediated destruction of insulin-producing β cells causes type 1 diabetes (T1D). However, how β cells participate in their own destruction during the disease process is poorly understood. Here, we report...