Hugh A Pearson
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Explore the profile of Hugh A Pearson including associated specialties, affiliations and a list of published articles.
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27
Citations
735
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Recent Articles
1.
Peroxynitrite mediates disruption of Ca2+ homeostasis by carbon monoxide via Ca2+ ATPase degradation
Hettiarachchi N, Boyle J, Bauer C, Dallas M, Pearson H, Hara S, et al.
Antioxid Redox Signal
. 2012 Feb;
17(5):744-55.
PMID: 22360385
Aim: Sublethal carbon monoxide poisoning causes prolonged neurological damage involving oxidative stress. Given the central role of Ca(2+) homeostasis and its vulnerability to stress, we investigated whether CO disrupts neuronal...
2.
Boyle J, Hettiarachchi N, Wilkinson J, Pearson H, Scragg J, Lendon C, et al.
Brain Res
. 2012 Feb;
1443:75-88.
PMID: 22297172
Mutations in the presenilin 1 (PS1) gene lead to early-onset Alzheimer's disease with the S170F mutation causing the earliest reported age of onset. Expression of this, and other PS1 mutations,...
3.
Dallas M, Boyle J, Milligan C, Sayer R, Kerrigan T, McKinstry C, et al.
FASEB J
. 2011 Jan;
25(5):1519-30.
PMID: 21248240
Oxidative stress induces neuronal apoptosis and is implicated in cerebral ischemia, head trauma, and age-related neurodegenerative diseases. An early step in this process is the loss of intracellular K(+) via...
4.
Hettiarachchi N, Dallas M, Pearson H, Bruce G, Deuchars S, Boyle J, et al.
Biochem Biophys Res Commun
. 2010 Jun;
397(3):564-8.
PMID: 20573603
Neuronal gap junctions are receiving increasing attention as a physiological means of intercellular communication, yet our understanding of them is poorly developed when compared to synaptic communication. Using microfluorimetry, we...
5.
Hettiarachchi N, Parker A, Dallas M, Pennington K, Hung C, Pearson H, et al.
J Neurochem
. 2009 Oct;
111(5):1192-201.
PMID: 19860837
Parkinson's disease (PD) is characterized in part by the presence of alpha-synuclein (alpha-syn) rich intracellular inclusions (Lewy bodies). Mutations and multiplication of the alpha-synuclein gene (SNCA) are associated with familial...
6.
Peers C, Dallas M, Boycott H, Scragg J, Pearson H, Boyle J
Ann N Y Acad Sci
. 2009 Oct;
1177:169-77.
PMID: 19845619
Periods of chronic hypoxia, which can arise from numerous cardiorespiratory disorders, predispose individuals to the development of dementias, particularly Alzheimer's disease (AD). AD is characterized in part by the increased...
7.
Milligan C, Li J, Sukumar P, Majeed Y, Dallas M, English A, et al.
Nat Protoc
. 2009 Feb;
4(2):244-55.
PMID: 19197268
Robotic multiwell planar patch-clamp has become common in drug development and safety programs because it enables efficient and systematic testing of compounds against ion channels during voltage-clamp. It has not,...
8.
Kerrigan T, Atkinson L, Peers C, Pearson H
Neuroreport
. 2008 May;
19(8):839-43.
PMID: 18463498
The Alzheimer's disease related peptide amyloid beta (Abeta) might have a physiological role in upregulating K channel currents in neurones. Earlier studies used the human form of Abeta1-40 on rat...
9.
Boycott H, Wilkinson J, Boyle J, Pearson H, Peers C
Glia
. 2008 Apr;
56(9):998-1004.
PMID: 18381653
Transporter-mediated glutamate uptake is a principal function of astrocytes. Our previous studies have shown that this process is compromised under hypoxic conditions through the NF-kappaB mediated inhibition of expression of...
10.
Boycott H, Dallas M, Boyle J, Pearson H, Peers C
Biochem Biophys Res Commun
. 2007 Oct;
364(1):100-4.
PMID: 17927959
Sustained hypoxia alters the expression of numerous proteins and predisposes individuals to Alzheimer's disease (AD). We have previously shown that hypoxia in vitro alters Ca2+ homeostasis in astrocytes and promotes...