Huali Chen
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Explore the profile of Huali Chen including associated specialties, affiliations and a list of published articles.
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Articles
74
Citations
699
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Recent Articles
1.
Zhang Q, Chen H, Wu L, Chen H
J Control Release
. 2024 Dec;
378:534-542.
PMID: 39701452
In recent years, polypeptides have been standing out as excellent candidates to replace polyethylene glycol (PEG) with adequate biocompatibility and biodegradability. In this study, we found that (VELPPP), an anionic...
2.
Zhang Z, Chen H, Li Q
Int Immunopharmacol
. 2024 Sep;
142(Pt B):113235.
PMID: 39332089
The disorder of gut microbiota has negative impact on male reproductive, and testicular damage is associated with obesity. However, the detailed mechanism of gut microbiota on the obesity-induced testis injury...
3.
Wu K, He M, Mao B, Xing Y, Wei S, Jiang D, et al.
J Control Release
. 2024 Aug;
374:293-311.
PMID: 39151831
The persistent presence of covalently closed circular DNA (cccDNA) in hepatocyte nuclei poses a significant obstacle to achieving a comprehensive cure for hepatitis B virus (HBV). Current applications of CRISPR/Cas9...
4.
Ren F, Gan Z, Zhang Q, He D, Chen B, Wu X, et al.
Drug Deliv Transl Res
. 2024 Aug;
15(3):939-954.
PMID: 39112826
ALK/HDACs dual target inhibitor (PT-54) was a 2,4-pyrimidinediamine derivative synthesized based on the pharmacophore merged strategy that inhibits both anaplastic lymphoma kinase (ALK) and histone deacetylases (HDACs), which has demonstrated...
5.
Chen H, Zhou X, Dai W
J Antimicrob Chemother
. 2024 Jul;
79(9):2298-2305.
PMID: 38990679
Background: Bacterial RNA polymerase (RNAP) is a promising target for antimicrobial chemotherapy due to its indispensable role in bacterial growth and survival. Among its components, only the rpoB gene encoding...
6.
Li X, Cheng J, Yao Q, Duan J, Chen H, Zhang Z, et al.
Mol Nutr Food Res
. 2024 Jul;
68(15):e2300904.
PMID: 38982688
Scope: Isorhamnetin is a natural flavonoid with various pharmacological activities, which can be widely and continuously ingested by humans and animals through their daily diet. The aim of this study...
7.
Cheng J, Yang L, Zhang Z, Xu D, Hua R, Chen H, et al.
Ecotoxicol Environ Saf
. 2024 Jun;
280:116562.
PMID: 38850704
Diquat dibromide (DQ) is a globally used herbicide in agriculture, and its overuse poses an important public health issue, including male reproductive toxicity in mammals. However, the effects and molecular...
8.
Qiu H, Li Y, Yuan M, Chen H, Dandekar A, Dai W
PLoS Pathog
. 2024 Mar;
20(3):e1012078.
PMID: 38484003
XRE-cupin family proteins containing an DNA-binding domain and a cupin signal-sensing domain are widely distributed in bacteria. In Pseudomonas aeruginosa, XRE-cupin transcription factors have long been recognized as regulators exclusively...
9.
Huang R, Chen H, Pi D, He X, Yu C, Yu C
Eur J Pharm Biopharm
. 2024 Mar;
198:114239.
PMID: 38452907
Etoposide (VP16) is commonly used in the treatment of small cell lung cancer (SCLC) in clinical practice. However, severe adverse reactions such as bone marrow suppression toxicity limit its clinical...
10.
Chen H, Zhang Q
Expert Opin Drug Deliv
. 2023 Dec;
21(1):1-12.
PMID: 38116624
Introduction: Due to the concerns raised by the extensive application of PEGylation, polypeptides have stood out as excellent candidates with adequate biocompatibility and biodegradability with tunable hydrophilicity. Areas Covered: In...