Hua-Dong Chen
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Explore the profile of Hua-Dong Chen including associated specialties, affiliations and a list of published articles.
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34
Citations
326
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Recent Articles
1.
Wang L, Wang P, Chen X, Yang H, Song S, Song Z, et al.
EMBO Mol Med
. 2023 Jan;
15(3):e16235.
PMID: 36652375
Poly-ADP-ribose polymerase (PARP) inhibitors (PARPi) have shown great promise for treating BRCA-deficient tumors. However, over 40% of BRCA-deficient patients fail to respond to PARPi. Here, we report that thioparib, a...
2.
Guo N, Li M, Wang L, Chen H, Song S, Miao Z, et al.
Cancer Biol Ther
. 2022 Jan;
23(1):69-82.
PMID: 35000525
PARP1 and Chk1 inhibitors have been shown to be synergistic in different cancer models in relatively short time treatment modes. However, the consequences of long-term/repeated treatments with the combinations in...
3.
Chen H, Li F, Chen S, Zhong Z, Gao P, Gao W
Cancer Gene Ther
. 2021 Nov;
29(7):1012-1020.
PMID: 34799724
N-methyladenosine (mA) RNA methylation and its associated methyltransferase METTL3 play an important role in tumorigenesis of a series of tumors. However, dysregulation of METTL3 in gallbladder cancer (GBC) remains obscure....
4.
Wang Y, Wang Q, Tang C, Chen H, Hu G, Shao J, et al.
Medicine (Baltimore)
. 2021 Mar;
100(10):e25124.
PMID: 33725911
Although some studies have reported the expression and clinical significance of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in breast cancer tissues, it is still controversial whether p-STAT3...
5.
Zhang N, Tian Y, Zhou L, Li M, Chen H, Song S, et al.
Cell Death Dis
. 2021 Feb;
12(2):183.
PMID: 33589588
Monotherapy with poly ADP-ribose polymerase (PARP) inhibitors results in a limited objective response rate (≤60% in most cases) in patients with homologous recombination repair (HRR)-deficient cancer, which suggests a high...
6.
Zhang D, Chen H, Zulfiqar H, Yuan S, Huang Q, Zhang Z, et al.
Comput Math Methods Med
. 2021 Jan;
2021:6664362.
PMID: 33505515
Bioluminescent proteins (BLPs) are a class of proteins that widely distributed in many living organisms with various mechanisms of light emission including bioluminescence and chemiluminescence from luminous organisms. Bioluminescence has...
7.
Shan Q, Liu B, Zhong Z, Chen H, Guo Y, Xie X, et al.
Indian J Pediatr
. 2020 Nov;
88(7):650-655.
PMID: 33216321
Objective: To compare the outcome of biliary atresia (BA) patients with and without hilar cyst on preoperative ultrasound. Methods: A single center retrospective review of patients of BA with (n ...
8.
Chen H, Guo N, Song S, Chen C, Miao Z, He J
Am J Cancer Res
. 2020 Oct;
10(9):2813-2831.
PMID: 33042619
Several poly(ADP ribose) polymerase (PARP) inhibitors (PARPi) have been approved for cancer therapy; however, intrinsic and acquired resistance has limited their efficacy in the clinic. In fact, cancer cells have...
9.
Zeng J, Zhang J, Yang Y, Wang F, Jiang H, Chen H, et al.
Am J Transl Res
. 2020 Sep;
12(8):4702-4714.
PMID: 32913543
Objective: To study the expression of IL13RA2 in gliomas and to analyze its correlation with clinicopathological/molecular features, immune cell infiltration and prognostic significance. Methods: mRNA expression data for IL13RA2 were...
10.
Chen H, Huang C, Xu Q, Li F, Huang X, Wang J, et al.
Int J Biol Sci
. 2020 Mar;
16(7):1207-1217.
PMID: 32174795
Intrahepatic cholangiocarcinoma (ICC) is a lethal malignancy with high mortality and lack of effective therapeutic targets. Here, we found that expression of cyclin-dependent kinase 7 (CDK7) was significantly associated with...