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Hsin-Chou Chen

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Articles 8
Citations 190
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Recent Articles
1.
Su Y, Chen H, Tsai R, Lin P, Cheng S
Nucleic Acids Res . 2018 Feb; 46(7):3764-3773. PMID: 29390077
Cwc23 is a member of the J protein family, and has been shown to interact with Ntr1, a scaffold protein that interacts with Ntr2 and Prp43 to form the NTR...
2.
Tseng C, Chung C, Chen H, Cheng S
RNA . 2017 Jan; 23(4):546-556. PMID: 28057857
Splicing of precursor mRNA occurs via two consecutive steps of transesterification reaction; both require ATP and several proteins. Despite the energy requirement in the catalytic phase, incubation of the purified...
3.
Chen H, Chang K, Su Y, Huang Y, Cheng S
Nucleic Acids Res . 2014 Oct; 42(19):12261-71. PMID: 25294830
The Prp19-associated complex is required for spliceosome activation by stabilizing the binding of U5 and U6 on the spliceosome after the release of U4. The complex comprises at least eight...
4.
Chen H, Tseng C, Tsai R, Chung C, Cheng S
Mol Cell Biol . 2012 Nov; 33(3):514-25. PMID: 23166295
The DEAH-box ATPase Prp43 is required for disassembly of the spliceosome after the completion of splicing or after the discard of the spliceosome due to a splicing defect. Prp43 associates...
5.
Chen H, Cheng S
Biosci Rep . 2012 Jul; 32(4):345-59. PMID: 22762203
RNA splicing is one of the fundamental processes in gene expression in eukaryotes. Splicing of pre-mRNA is catalysed by a large ribonucleoprotein complex called the spliceosome, which consists of five...
6.
Chang K, Chen H, Cheng S
RNA . 2009 Jul; 15(9):1729-39. PMID: 19617314
The Prp19-associated complex (NineTeen Complex [NTC]) is required for spliceosome activation by specifying interactions of U5 and U6 with pre-mRNA on the spliceosome after the release of U4. The NTC...
7.
Tsai R, Tseng C, Lee P, Chen H, Fu R, Chang K, et al.
Mol Cell Biol . 2007 Sep; 27(23):8027-37. PMID: 17893323
The Saccharomyces cerevisiae splicing factors Ntr1 (also known as Spp382) and Ntr2 form a stable complex and can further associate with DExD/H-box RNA helicase Prp43 to form a functional complex,...
8.
Liu Y, Chen H, Wu N, Cheng S
Mol Cell Biol . 2007 May; 27(15):5403-13. PMID: 17515604
The Prp19-associated complex (NTC) is essential for pre-mRNA splicing and is associated with the spliceosome during spliceosome activation. NTC is required for specifying interactions of U5 and U6 with pre-mRNA...