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Hsiao-Mei Wu

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Articles 15
Citations 174
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Recent Articles
1.
Liu Y, Chung M, Lin H, Lee T, Cheng Y, Huang C, et al.
Sci Adv . 2025 Mar; 11(11):eado1164. PMID: 40073136
Oxygen plays a critical role in early neural development in brains, particularly before establishment of complete vasculature; however, it has seldom been investigated due to technical limitations. This study uses...
2.
Kannan S, Peng C, Wu H, Tung Y
Biosensors (Basel) . 2024 Feb; 14(2). PMID: 38392015
Oxygen consumption has been used to evaluate various cellular activities. In addition, three-dimensional (3D) spheroids have been broadly exploited as advanced in vitro cell models for various biomedical studies due...
3.
Chang D, Hsu H, Ko P, Chang W, Hsieh T, Wu H, et al.
Analyst . 2024 Feb; 149(6):1727-1737. PMID: 38375547
Understanding the influence of oxygen tension on cellular functions and behaviors is crucial for investigating various physiological and pathological conditions. cell culture models, particularly those based on hydrogel extracellular matrices,...
4.
Kannan S, Ko P, Wu H, Tung Y
Biomicrofluidics . 2023 Oct; 17(5):054105. PMID: 37840539
Cell metabolism is critical in regulating normal cell functions to maintain energy homeostasis. In order to monitor cell metabolism, the oxygen consumption rate (OCR) of cells has been characterized as...
5.
Hsu H, Ko P, Peng C, Cheng Y, Wu H, Tung Y
Mater Today Bio . 2023 Jul; 21:100703. PMID: 37483382
Sprouting angiogenesis is an essential process for expanding vascular systems under various physiological and pathological conditions. In this paper, a microfluidic device capable of integrating a hydrogel matrix for cell...
6.
Sarkar S, Peng C, Kuo C, Chueh D, Wu H, Liu Y, et al.
RSC Adv . 2022 May; 8(53):30320-30329. PMID: 35546825
Three-dimensional cell spheroid culture using microfluidic devices provides a convenient model for studying tumour spheroid structures and internal microenvironments. Recent studies suggest that oxygen deprived zones inside solid tumors are...
7.
Hsu H, Ko P, Wu H, Lin H, Wang C, Tung Y
Small . 2021 Jan; 17(15):e2006091. PMID: 33480473
Formation of 3D networks is a crucial process for endothelial cells during development of primary blood vessels under both normal and pathological conditions. In order to investigate effects of oxygen...
8.
Shih H, Lee T, Wu H, Ko P, Liao W, Tung Y
Sci Rep . 2019 Jun; 9(1):8234. PMID: 31160651
Proliferation and migration of endothelial cells play an important role in many biological activities, and they can be regulated by various microenvironmental factors. In this paper, a novel microfluidic collective...
9.
Wu H, Lee T, Ko P, Liao W, Hsieh T, Tung Y
Analyst . 2019 May; 144(11):3494-3504. PMID: 31062784
An oxygen gradient is a key variable influencing various biological activities in vivo, such as tissue repair and tumor growth. To study the phenomenon, in vitro cell studies using microfluidic...
10.
Wang C, Liao W, Wu H, Tung Y
J Vis Exp . 2018 Oct; (139). PMID: 30272670
Polydimethylsiloxane (PDMS) materials are substantially exploited to fabricate microfluidic devices by using soft lithography replica molding techniques. Customized channel layout designs are necessary for specific functions and integrated performance of...