Hsiao-Jou Cortina Chen
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Explore the profile of Hsiao-Jou Cortina Chen including associated specialties, affiliations and a list of published articles.
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24
Citations
209
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Recent Articles
1.
Chen H, Spiers J, Lerskiatiphanich T, Parker S, Lavidis N, Fung J, et al.
Biol Psychiatry Glob Open Sci
. 2024 Apr;
4(3):100306.
PMID: 38628385
Background: Accumulating evidence underscores the pivotal role of heightened inflammation in the pathophysiology of stress-related diseases, but the underlying mechanisms remain elusive. The complement system, a key effector of the...
2.
Zhao Y, Chukanova M, Kentistou K, Fairhurst-Hunter Z, Siegert A, Jia R, et al.
Nat Genet
. 2024 Apr;
56(4):579-584.
PMID: 38575728
Obesity is a major risk factor for many common diseases and has a substantial heritable component. To identify new genetic determinants, we performed exome-sequence analyses for adult body mass index...
3.
Jorgensen S, Karnosova A, Mazzaferro S, Rowley O, Chen H, Robbins S, et al.
EMBO Rep
. 2024 Jan;
25(1):351-377.
PMID: 38177913
Hypothalamic Adult Neurogenesis (hAN) has been implicated in regulating energy homeostasis. Adult-generated neurons and adult Neural Stem Cells (aNSCs) in the hypothalamus control food intake and body weight. Conversely, diet-induced...
4.
Chen H, Mazzaferro S, Tian T, Mali I, Merkle F
Curr Protoc
. 2023 Jun;
3(6):e786.
PMID: 37272700
Neurons in the hypothalamus orchestrate homeostatic physiological processes and behaviors essential for life. Human pluripotent stem cells (hPSCs) can be differentiated into many types of hypothalamic neurons, progenitors, and glia....
5.
Spiers J, Chen H, Steinert J
PLoS Pathog
. 2023 Apr;
19(4):e1011309.
PMID: 37104170
Prion diseases, also known as transmissible spongiform encephalopathies, are rare, progressive, and fatal neurodegenerative disorders, which are caused by the accumulation of the misfolded cellular prion protein (PrPC). The resulting...
6.
Spiers J, Chen H, Barry T, Bourgognon J, Steinert J
Free Radic Biol Med
. 2022 Sep;
192:182-190.
PMID: 36170956
Neurodegenerative diseases are associated with a multitude of dysfunctional cellular pathways. One major contributory factor is a redox stress challenge during the development of several protein misfolding conditions including Alzheimer's...
7.
Spiers J, Tan L, Anderson S, Hill A, Lavidis N, Chen H
Antioxidants (Basel)
. 2022 Jan;
11(1).
PMID: 35052588
Essential metals such as copper, iron, and zinc are cofactors in various biological processes including oxygen utilisation, cell growth, and biomolecular synthesis. The homeostasis of these essential metals is carefully...
8.
Spiers J, Steiger N, Khadka A, Juliani J, Hill A, Lavidis N, et al.
Biochimie
. 2020 Oct;
180:30-42.
PMID: 33122103
Bidirectional communication between the neuroendocrine stress and immune systems permits classically anti-inflammatory glucocorticoids to exert pro-inflammatory effects in specific cells and tissues. Liver macrophages/Kupffer cells play a crucial role in...
9.
Chen H, Yip T, Lee J, Juliani J, Sernia C, Hill A, et al.
Antioxidants (Basel)
. 2020 Sep;
9(9).
PMID: 32932938
Hepatic glutathione synthesis and antioxidant protection are critically important for efficient detoxification processes in response to metabolic challenges. However, this biosynthetic pathway, regulated by nuclear factor (erythroid-derived 2)-like 2 (Nrf2),...
10.