Hristelina Ilieva
Overview
Explore the profile of Hristelina Ilieva including associated specialties, affiliations and a list of published articles.
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17
Citations
1347
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Recent Articles
1.
Berry J, Maragakis N, Macklin E, Chibnik L, Quintana M, Saville B, et al.
JAMA
. 2025 Mar;
PMID: 40067821
Importance: Bioenergetic failure has been proposed as a driver of amyotrophic lateral sclerosis (ALS). CNM-Au8 is a suspension of gold nanocrystals that catalyzes the conversion of nicotinamide adenine dinucleotide hydride...
2.
Shefner J, Oskarsson B, Macklin E, Chibnik L, Quintana M, Saville B, et al.
JAMA
. 2025 Mar;
PMID: 40067755
Importance: Amyotrophic lateral sclerosis (ALS) is a fatal disease. The sigma-1 (σ1) receptor emerged as a target for intervention. Objective: To determine the effects of pridopidine, a σ1-receptor agonist, in...
3.
Verdiperstat in Amyotrophic Lateral Sclerosis: Results From the Randomized HEALEY ALS Platform Trial
Andrews J, Paganoni S, Macklin E, Chibnik L, Quintana M, Saville B, et al.
JAMA Neurol
. 2025 Mar;
PMID: 40067754
Importance: Myeloperoxidase is one of the most abundant peroxidase enzymes in activated myeloid cells. Myeloperoxidase inhibitors may have a clinical benefit in amyotrophic lateral sclerosis (ALS) by slowing neurodegeneration via...
4.
Loher P, Londin E, Ilieva H, Pasinelli P, Rigoutsos I
Mol Neurobiol
. 2025 Feb;
PMID: 39982687
Amyotrophic lateral sclerosis (ALS) is a highly heterogeneous disease for which accurate diagnostic and prognostic biomarkers are needed. Toward this goal, we reanalyzed two published collections of datasets generated from...
5.
Paganoni S, Fournier C, Macklin E, Chibnik L, Quintana M, Saville B, et al.
JAMA Netw Open
. 2025 Feb;
8(2):e2459058.
PMID: 39960672
Importance: The etiology of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, is unknown. However, neuroinflammation and complement activation may play a role in disease progression. Objective: To determine the...
6.
Ilieva H, Vullaganti M, Kwan J
BMJ
. 2023 Oct;
383:e075037.
PMID: 37890889
Although the past two decades have produced exciting discoveries in the genetics and pathology of amyotrophic lateral sclerosis (ALS), progress in developing an effective therapy remains slow. This review summarizes...
7.
Jensen B, McAvoy K, Heinsinger N, Lepore A, Ilieva H, Haeusler A, et al.
Glia
. 2022 Apr;
70(7):1426-1449.
PMID: 35474517
Genetic mutations that cause amyotrophic lateral sclerosis (ALS), a progressively lethal motor neuron disease, are commonly found in ubiquitously expressed genes. In addition to direct defects within motor neurons, growing...
8.
Pinilla G, Kumar A, Floaters M, Pardo C, Rothstein J, Ilieva H
Amyotroph Lateral Scler Frontotemporal Degener
. 2021 Apr;
22(7-8):517-527.
PMID: 33929933
C9ORF72 hexanucleotide expansion is the most common genetic cause of familial amyotrophic lateral sclerosis (ALS)/fronto-temporal dementia (FTD) disease spectrum. Even though three major mechanisms of disease pathogenesis have been proposed,...
9.
Ling S, Ghosh Dastidar S, Tokunaga S, Ho W, Lim K, Ilieva H, et al.
Elife
. 2019 Feb;
8.
PMID: 30747709
Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS). The latter mutations may exert toxicity by increasing FUS accumulation. We show here that broad expression within...
10.
Ilieva H, Maragakis N
Adv Neurobiol
. 2017 Jul;
15:191-210.
PMID: 28674982
ALS is a neurodegenerative disease in which the primary symptoms result in progressive neuromuscular weakness. Recent studies have highlighted that there is significant heterogeneity with regard to anatomical and temporal...