Howard M Cann
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Explore the profile of Howard M Cann including associated specialties, affiliations and a list of published articles.
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12
Citations
3024
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Recent Articles
1.
Martin A, Costa H, Lappalainen T, Henn B, Kidd J, Yee M, et al.
PLoS Genet
. 2014 Aug;
10(8):e1004549.
PMID: 25121757
Large-scale sequencing efforts have documented extensive genetic variation within the human genome. However, our understanding of the origins, global distribution, and functional consequences of this variation is far from complete....
2.
Patillon B, Luisi P, Blanche H, Patin E, Cann H, Genin E, et al.
PLoS One
. 2013 Jan;
7(12):e53049.
PMID: 23285254
VKORC1 (vitamin K epoxide reductase complex subunit 1, 16p11.2) is the main genetic determinant of human response to oral anticoagulants of antivitamin K type (AVK). This gene was recently suggested...
3.
Mandel J, Lathrop M, Cann H
Eur J Hum Genet
. 2009 Oct;
17(11):1365-6.
PMID: 19847273
No abstract available.
4.
Li J, Absher D, Tang H, Southwick A, Casto A, Ramachandran S, et al.
Science
. 2008 Feb;
319(5866):1100-4.
PMID: 18292342
Human genetic diversity is shaped by both demographic and biological factors and has fundamental implications for understanding the genetic basis of diseases. We studied 938 unrelated individuals from 51 populations...
5.
Jakobsson M, Scholz S, Scheet P, Gibbs J, Vanliere J, Fung H, et al.
Nature
. 2008 Feb;
451(7181):998-1003.
PMID: 18288195
Genome-wide patterns of variation across individuals provide a powerful source of data for uncovering the history of migration, range expansion, and adaptation of the human species. However, high-resolution surveys of...
6.
Feigelson H, Cox D, Cann H, Wacholder S, Kaaks R, Henderson B, et al.
Cancer Res
. 2006 Feb;
66(4):2468-75.
PMID: 16489054
The 17beta-hydroxysteroid dehydrogenase 1 gene (HSD17B1) encodes 17HSD1, which catalyzes the final step of estradiol biosynthesis. Despite the important role of HSD17B1 in hormone metabolism, few epidemiologic studies of HSD17B1...
7.
Barreiro L, Patin E, Neyrolles O, Cann H, Gicquel B, Quintana-Murci L
Am J Hum Genet
. 2005 Oct;
77(5):869-86.
PMID: 16252244
The innate immunity system constitutes the first line of host defense against pathogens. Two closely related innate immunity genes, CD209 and CD209L, are particularly interesting because they directly recognize a...
8.
Sirugo G, Schim van der Loeff M, Sam O, Nyan O, Pinder M, Hill A, et al.
Nat Genet
. 2004 Jul;
36(8):785-6.
PMID: 15284842
No abstract available.
9.
Horton R, Rosenberg N, Pritchard J, Weber J, Cann H, Kidd K, et al.
Lancet
. 2003 Dec;
362(9401):2101-3.
PMID: 14697815
No abstract available.
10.
Matise T, Sachidanandam R, Clark A, Kruglyak L, Wijsman E, Kakol J, et al.
Am J Hum Genet
. 2003 Jul;
73(2):271-84.
PMID: 12844283
Recent advances in technologies for high-throughout single-nucleotide polymorphism (SNP)-based genotyping have improved efficiency and cost so that it is now becoming reasonable to consider the use of SNPs for genomewide...