Howard C Thomas
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Explore the profile of Howard C Thomas including associated specialties, affiliations and a list of published articles.
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68
Citations
2836
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Recent Articles
1.
Wadsworth C, Dixon P, Taylor-Robinson S, Kim J, Zabron A, Wong J, et al.
J Clin Exp Hepatol
. 2019 Apr;
9(2):171-175.
PMID: 31024198
Background And Aims: Understanding of the significant genetic risk factors for Cholangiocarcinoma (CC) remains limited. Polymorphisms in the natural killer cell receptor G2D (NKG2D) gene have been shown to increase...
2.
McCabe W, Way M, Ruparelia K, Knapp S, Ali M, Anstee Q, et al.
Psychiatr Genet
. 2017 Mar;
27(3):110-115.
PMID: 28346242
Associations between the γ-aminobutyric acid type-A receptors (GABAA) and alcohol dependence risk have been reported, although the receptor subunit driving the association is unclear. Recent work in mice has highlighted...
3.
Bridge S, Sheridan D, Felmlee D, Crossey M, Fenwick F, Lanyon C, et al.
J Hepatol
. 2014 Dec;
62(4):763-70.
PMID: 25463543
Background & Aims: Hepatitis C virus (HCV) associates with lipoproteins to form "lipoviral particles" (LVPs) that can facilitate viral entry into hepatocytes. Initial attachment occurs via heparan sulphate proteoglycans and...
4.
Anstee Q, Knapp S, Maguire E, Hosie A, Thomas P, Mortensen M, et al.
Nat Commun
. 2013 Nov;
4:2816.
PMID: 24281383
Alcohol dependence is a common, complex and debilitating disorder with genetic and environmental influences. Here we show that alcohol consumption increases following mutations to the γ-aminobutyric acidA receptor (GABAAR) β1...
5.
Sheridan D, Bridge S, Crossey M, Felmlee D, Fenwick F, Thomas H, et al.
Liver Int
. 2013 Oct;
34(5):737-47.
PMID: 24118830
Background & Aims: Hepatitis C virus (HCV) utilises cholesterol and lipoprotein metabolism for replication and infectivity. Statins and omega-3 (n-3) polyunsaturated fatty acids (PUFA) have been shown to have antiviral...
6.
McPhail M, Leech R, Grover V, Fitzpatrick J, Dhanjal N, Crossey M, et al.
Neurology
. 2013 Feb;
80(11):1041-7.
PMID: 23427320
Objective: To measure changes in psychometric state, neural activation, brain volume (BV), and cerebral metabolite concentrations during treatment of minimal hepatic encephalopathy. Methods: As proof of principle, 22 patients with...
7.
Khan S, Davidson B, Goldin R, Heaton N, Karani J, Pereira S, et al.
Gut
. 2012 Aug;
61(12):1657-69.
PMID: 22895392
The British Society of Gastroenterology guidelines on the management of cholangiocarcinoma were originally published in 2002. This is the first update since then and is based on a comprehensive review...
8.
Cobbold J, Cox I, Brown A, Williams H, Goldin R, Thomas H, et al.
Hepatol Res
. 2012 Jun;
42(7):714-20.
PMID: 22686859
Aim: Hepatic lipid is important in the pathogenesis and progression of hepatitis C-related liver disease. Polyunsaturated fatty acids have been shown to reduce viral replication in cell culture. Proton magic...
9.
Cobbold J, Patel D, Fitzpatrick J, Patel N, Crossey M, Abdalla M, et al.
Hepatol Res
. 2012 Apr;
42(5):515-22.
PMID: 22502745
Aim: Contrast-enhanced ultrasound can be used to assess liver disease severity non-invasively by observing intra- and extrahepatic hemodynamic changes. Transit times are calculated to include intra- and extrahepatic components (hepatic...
10.
Sheridan D, Bridge S, Felmlee D, Crossey M, Thomas H, Taylor-Robinson S, et al.
J Hepatol
. 2012 Mar;
57(1):32-8.
PMID: 22414761
Background & Aims: Hepatitis C virus (HCV) interacts with apolipoproteins B (apoB) and E (apoE) to form infectious lipoviral particles (LVP). Response to peginterferon is influenced by interferon-stimulated genes (ISGs)...