Howard C Dittrich
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Explore the profile of Howard C Dittrich including associated specialties, affiliations and a list of published articles.
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51
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1390
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Recent Articles
1.
Nakamura K, Henry T, Traverse J, Latter D, Mokadam N, Answini G, et al.
Circ Cardiovasc Interv
. 2024 May;
17(5):e014054.
PMID: 38696284
Background: XC001 is a novel adenoviral-5 vector designed to express multiple isoforms of VEGF (vascular endothelial growth factor) and more safely and potently induce angiogenesis. The EXACT trial (Epicardial Delivery...
2.
Stewart D, Gianchetti A, Byrnes D, Dittrich H, Thorne B, Manza L, et al.
Gene Ther
. 2023 Aug;
31(1-2):45-55.
PMID: 37592080
Adenovirus-mediated gene therapy holds promise for the treatment of cardiovascular diseases such as refractory angina. However, potential concerns around immunogenicity and vector dissemination from the target injected tissue require evaluation....
3.
Povsic T, Henry T, Traverse J, Anderson R, Answini G, Sun B, et al.
Circ Cardiovasc Interv
. 2023 Jul;
16(8):e012997.
PMID: 37503661
Background: New therapies are needed for patients with refractory angina. Encoberminogene rezmadenovec (XC001), a novel adenoviral-5 vector coding for all 3 major isoforms of VEGF (vascular endothelial growth factor), demonstrated...
4.
Davison B, Edwards C, Loomba R, Harrison S, Cotter G, Alkhouri N, et al.
JGH Open
. 2021 Jul;
5(7):740-749.
PMID: 34263067
Background And Aim: Liver histology changes are the current gold standard for evaluating non-alcoholic steatohepatitis (NASH), but are limited by their invasiveness and variability for sampling and interpretation. We evaluated...
5.
Povsic T, Henry T, Ohman E, Pepine C, Crystal R, Rosengart T, et al.
Am Heart J
. 2021 Jul;
241:38-49.
PMID: 34224684
Background: Patients with refractory angina (RA) have poor quality of life and new therapies are needed. XC001 is a novel adenoviral vector expressing multiple isoforms of vascular endothelial growth factor...
6.
Davison B, Harrison S, Cotter G, Alkhouri N, Sanyal A, Edwards C, et al.
J Hepatol
. 2020 Jul;
73(6):1322-1332.
PMID: 32610115
Background & Aims: Liver biopsies are a critical component of pivotal studies in non-alcoholic steatohepatitis (NASH), constituting inclusion criteria, risk stratification factors and endpoints. We evaluated the reliability of NASH...
7.
Harrison S, Alkhouri N, Davison B, Sanyal A, Edwards C, Colca J, et al.
J Hepatol
. 2019 Nov;
72(4):613-626.
PMID: 31697972
Background & Aims: MSDC-0602K is a novel insulin sensitizer designed to preferentially target the mitochondrial pyruvate carrier while minimizing direct binding to the transcriptional factor PPARγ. Herein, we aimed to...
8.
Beldhuis I, Streng K, van der Meer P, Ter Maaten J, OConnor C, Metra M, et al.
J Card Fail
. 2019 Jul;
25(11):866-874.
PMID: 31319165
Background: Changes in renal function have been associated with differential outcomes in patients with acute heart failure (HF). However, individual trajectories of changes in renal function are unknown, and it...
9.
Ferdinand K, Balavoine F, Besse B, Black H, Desbrandes S, Dittrich H, et al.
Circulation
. 2019 Apr;
140(2):138-146.
PMID: 31014072
Background: Despite existing therapy, successful control of hypertension in the United States is estimated at less than 50%. In blacks, hypertension occurs earlier, is more severe, controlled less often and...
10.
Metra M, Cotter G, Senger S, Edwards C, Cleland J, Ponikowski P, et al.
Circ Heart Fail
. 2018 May;
11(5):e004644.
PMID: 29748350
Background: The importance of a serum creatinine increase, traditionally considered worsening renal function (WRF), during admission for acute heart failure has been recently debated, with data suggesting an interaction between...