Hooman Noorchashm
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Explore the profile of Hooman Noorchashm including associated specialties, affiliations and a list of published articles.
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26
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450
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Recent Articles
11.
Vivek K, Mustafa M, Rodriguez E, Redfield 3rd R, Parsons R, Rostami S, et al.
Immunol Res
. 2011 Sep;
51(1):1-4.
PMID: 21948256
Transplantation tolerance remains an elusive goal as B-cell-initiated chronic humoral rejection evades current immunosuppression. B-cell-directed therapy is thus emerging as a key component in achieving transplantation tolerance and long-term graft...
12.
Parsons R, Vivek K, Rostami S, Zekavat G, Ziaie S, Luo Y, et al.
J Immunol
. 2010 Nov;
186(1):614-20.
PMID: 21084661
A major obstacle to transplantation tolerance is humoral immunity. In this paper, we demonstrate that the intrinsic developmental propensity of the B lymphocyte compartment for acquisition of self-tolerance can be...
13.
Parsons R, Vivek K, Redfield 3rd R, Migone T, Cancro M, Naji A, et al.
Transplant Rev (Orlando)
. 2010 Jul;
24(4):207-21.
PMID: 20655723
Current strategies for immunotherapy after transplantation are primarily T-lymphocyte directed and effectively abrogate acute rejection. However, the reality of chronic allograft rejection attests to the fact that transplantation tolerance remains...
14.
Zekavat G, Mozaffari R, Arias V, Rostami S, Badkerhanian A, Tenner A, et al.
Immunogenetics
. 2010 Apr;
62(6):397-407.
PMID: 20387063
In the present study, we characterize a polymorphism in the CD93 molecule, originally identified as the receptor for the C1q complement component (i.e., C1qRp, or AA4.1) in non-obese diabetic (NOD)...
15.
Parsons R, Vivek K, Redfield R, Migone T, Cancro M, Naji A, et al.
Expert Rev Clin Immunol
. 2010 Feb;
5(6):703.
PMID: 20161663
T lymphocytes are the primary targets of immunotherapy in clinical transplantation; however, B lymphocytes and their secreted alloantibodies are also highly detrimental to the allograft. Therefore, the achievement of sustained...
16.
Zekavat G, Rostami S, Badkerhanian A, Parsons R, Koeberlein B, Yu M, et al.
J Immunol
. 2008 Nov;
181(11):8133-44.
PMID: 19018006
B lymphocytes are required for the pathogenesis of autoimmune diabetes in NOD mice. Previous studies established that a lymphopenic transitional (TR) B cell compartment reduces the competitive constraint on the...
17.
B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates
Liu C, Noorchashm H, Sutter J, Naji M, Prak E, Boyer J, et al.
Nat Med
. 2007 Oct;
13(11):1295-8.
PMID: 17965721
We found that an induction immunotherapy regimen consisting of rabbit anti-thymocyte globulin (Thymoglobulin) and the monoclonal antibody to CD20 rituximab (Rituxan) promoted long-term islet allograft survival in cynomolgus macaques maintained...
18.
Noorchashm H, Reed A, Rostami S, Mozaffari R, Zekavat G, Koeberlein B, et al.
J Immunol
. 2006 Nov;
177(11):7715-22.
PMID: 17114442
Acute allograft rejection requires the activation of alloreactive CD4 T cells. Despite the capacity of B cells to act as potent APCs capable of activating CD4 T cells in vivo,...
19.
Quinn 3rd W, Noorchashm N, Crowley J, Reed A, Noorchashm H, Naji A, et al.
J Immunol
. 2006 Jun;
176(12):7159-64.
PMID: 16751358
Developing B cells undergo selection at multiple checkpoints to eliminate autoreactive clones. We analyzed B cell kinetics in the NOD mouse to establish whether these checkpoints are intact. Our results...
20.
Reed A, Zarrabi Y, Perate A, Jeganathan A, Naji A, Noorchashm H
Immunology
. 2005 Oct;
116(3):400-7.
PMID: 16236130
The present study aimed to determine whether the frequency of double positive (DP) thymocytes expressing alphabeta T-cell receptor (TCR) clonotypes at the time of selection regulates peripheral CD4 T-cell compartment...