Hongwen Xuan
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Explore the profile of Hongwen Xuan including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
145
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Recent Articles
1.
Xue Z, Xuan H, Lau K, Su Y, Wegener M, Li K, et al.
Nat Commun
. 2025 Mar;
16(1):2531.
PMID: 40087269
Recurrent gain-of-function mutations in the histone reader protein ENL have been identified in Wilms tumor, the most prevalent pediatric kidney cancer. However, their pathological significance in kidney development and tumorigenesis...
2.
Vann K, Sharma R, Hsu C, Devoucoux M, Tencer A, Zeng L, et al.
Nat Commun
. 2025 Mar;
16(1):2235.
PMID: 40044670
The histone H3K36-specific methyltransferase ASH1L plays a critical role in development and is frequently dysregulated in human diseases, particularly cancer. Here, we report on the biological functions of the C-terminal...
3.
Xu L, Xuan H, Shi X
Epigenomics
. 2025 Feb;
17(3):193-208.
PMID: 39929233
p300 (E1A binding protein 300) and CBP (CREB-binding protein) are critical regulators of chromatin dynamics and gene expression, playing essential roles in various cellular processes, including proliferation, differentiation, apoptosis, and...
4.
Yu H, Ren S, Xuan H, Wang Y
Opt Express
. 2024 Nov;
32(17):29483-29493.
PMID: 39573137
Two-photon microscopy (TPM) has a wide range of applications in the biomedical field. Two-photon multi-focus microscopy (TPMM) greatly improves the imaging speed by combining TPM with multi-focus technology. Therefore, TPMM...
5.
Xue Z, Qin L, Xuan H, Luo K, Huang M, Xie L, et al.
Sci Adv
. 2024 Aug;
10(35):eado1432.
PMID: 39196923
The histone acylation reader eleven-nineteen leukemia (ENL) plays a pivotal role in sustaining oncogenesis in acute leukemias, particularly in -rearranged (-r) leukemia. ENL relies on its reader domain to recognize...
6.
Liu L, Heng X, Xuan H
Appl Opt
. 2024 Jun;
63(12):3187-3191.
PMID: 38856466
In this work, we propose an integrated terahertz mode adapter that couples broadband terahertz radiation from free-space to hollow-core fiber with a high mode conversion efficiency (Gaussian beam-to- ) of...
7.
Liu H, Xuan H, Chen H, Hao J, Wu F, Zhang S, et al.
Opt Lett
. 2024 Mar;
49(5):1157-1160.
PMID: 38426962
High-power femtosecond pulses delivered at a high-repetition rate will aid machining throughput and improve signal-to-noise ratios for sensitive measurements. Here we demonstrate a Kerr-lens mode-locked femtosecond Yb:YAG ring-cavity thin-disk oscillator...
8.
Xuan F, Xuan H, Huang M, He W, Xu H, Shi X, et al.
J Mol Biol
. 2023 Dec;
436(7):168414.
PMID: 38141874
The lysine acetyltransferase KAT5 is a pivotal enzyme responsible for catalyzing histone H4 acetylation in cells. In addition to its indispensable HAT domain, KAT5 also encompasses a conserved Tudor-knot domain...
9.
Xuan H, Xu L, Li K, Xuan F, Xu T, Wen H, et al.
J Mol Biol
. 2023 Dec;
436(7):168413.
PMID: 38135180
KAT8 is an evolutionarily conserved lysine acetyltransferase that catalyzes histone acetylation at H4K16 or H4K5 and H4K8 through distinct protein complexes. It plays a pivotal role in male X chromosome...
10.
Xu L, Xuan H, He W, Zhang L, Huang M, Li K, et al.
Nat Commun
. 2023 Sep;
14(1):5362.
PMID: 37660055
The histone acetyltransferase p300/CBP is composed of several conserved domains, among which, the TAZ2 domain is known as a protein-protein interaction domain that binds to E1A and various transcription factors....