Holly Shelton
Overview
Explore the profile of Holly Shelton including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
1070
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Recent Articles
1.
Hohensee L, Scheibner D, Luttermann C, Shelton H, Dorhoi A, Abdelwhab E, et al.
Virus Res
. 2024 Aug;
349:199444.
PMID: 39089370
Avian influenza viruses (AIV) pose a continuous challenge to global health and economy. While countermeasures exist to control outbreaks in poultry, the persistent circulation of AIV in wild aquatic and...
2.
Rabeeah I, Billington E, Nal B, Sadeyen J, Pathan A, Iqbal M, et al.
Front Immunol
. 2024 May;
15:1352022.
PMID: 38698856
The complement system is an innate immune mechanism against microbial infections. It involves a cascade of effector molecules that is activated via classical, lectin and alternative pathways. Consequently, many pathogens...
3.
Hohensee L, Scheibner D, Schafer A, Shelton H, Mettenleiter T, Breithaupt A, et al.
Vet Res
. 2024 Jan;
55(1):5.
PMID: 38173025
Avian influenza viruses (AIV) of the H7N7 subtype are enzootic in the wild bird reservoir in Europe, cause infections in poultry, and have sporadically infected humans. The non-structural protein PB1-F2...
4.
Bialy D, Richardson S, Chrzastek K, Bhat S, Polo N, Freimanis G, et al.
Virology
. 2023 Dec;
590:109954.
PMID: 38086284
The possible emergence of drug-resistant avian flu raises concerns over the limited effectiveness of currently approved antivirals (neuraminidase inhibitors - NAIs) in the hypothetical event of a zoonotic spillover. Our...
5.
Idoko-Akoh A, Goldhill D, Sheppard C, Bialy D, Quantrill J, Sukhova K, et al.
Nat Commun
. 2023 Oct;
14(1):6136.
PMID: 37816720
Chickens genetically resistant to avian influenza could prevent future outbreaks. In chickens, influenza A virus (IAV) relies on host protein ANP32A. Here we use CRISPR/Cas9 to generate homozygous gene edited...
6.
Davis T, Bialy D, Leng J, La Ragione R, Shelton H, Chrzastek K
Pathogens
. 2023 Sep;
12(9).
PMID: 37764976
Several studies have highlighted the importance of the gut microbiota in developing immunity against viral infections in chickens. We have previously shown that H9N2 avian influenza A virus (AIV) infection...
7.
Nazki S, Reddy V, Kamble N, Sadeyen J, Iqbal M, Behboudi S, et al.
Front Immunol
. 2023 Sep;
14:1197746.
PMID: 37744374
Introduction: Infectious Bursal Disease Virus (IBDV) causes immunosuppression in chickens. While B-cell destruction is the main cause of humoral immunosuppression, bursal T cells from IBDV-infected birds have been reported to...
8.
Chrzastek K, Tennakoon C, Bialy D, Freimanis G, Flannery J, Shelton H
BMC Genomics
. 2022 Jun;
23(1):406.
PMID: 35644636
Background: Non-targeted whole genome sequencing is a powerful tool to comprehensively identify constituents of microbial communities in a sample. There is no need to direct the analysis to any identification...
9.
Bhat S, James J, Sadeyen J, Mahmood S, Everest H, Chang P, et al.
J Virol
. 2022 Jan;
96(5):e0185621.
PMID: 35019727
An H7N9 low-pathogenicity avian influenza virus (LPAIV) emerged in 2013 through genetic reassortment between H9N2 and other LPAIVs circulating in birds in China. This virus causes inapparent clinical disease in...
10.
Chrzastek K, Leng J, Zakaria M, Bialy D, La Ragione R, Shelton H
Anim Microbiome
. 2021 Sep;
3(1):64.
PMID: 34583770
Background: A commensal microbiota regulates and is in turn regulated by viruses during host infection which can influence virus infectivity. In this study, analysis of colon microbiota population changes following...