Holly Robertson
Overview
Explore the profile of Holly Robertson including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
575
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0
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Recent Articles
1.
Bathish B, Robertson H, Dillon J, Dinkova-Kostova A, Hayes J
Free Radic Biol Med
. 2022 Jun;
188:221-261.
PMID: 35728768
Non-alcoholic steatohepatitis (NASH) represents a global health concern. It is characterised by fatty liver, hepatocyte cell death and inflammation, which are associated with lipotoxicity, endoplasmic reticulum (ER) stress, mitochondrial dysfunction,...
2.
Thompson N, Ranzani M, van der Weyden L, Iyer V, Offord V, Droop A, et al.
Nat Commun
. 2021 Feb;
12(1):1302.
PMID: 33637726
Genetic redundancy has evolved as a way for human cells to survive the loss of genes that are single copy and essential in other organisms, but also allows tumours to...
3.
Kochar A, Summers M, Benziger C, Marquis-Gravel G, DeWalt D, Pepine C, et al.
Clin Trials
. 2021 Feb;
18(4):449-456.
PMID: 33541120
Background: ADAPTABLE (Aspirin Dosing: A Patient-centric Trial Assessing Benefits and Long-Term Effectiveness) is a pragmatic clinical trial examining high-dose versus low-dose aspirin among patients with cardiovascular disease. ADAPTABLE is leveraging...
4.
Marquis-Gravel G, Robertson H, Jones W, Riley D, Ford D, Crenshaw D, et al.
Trials
. 2021 Jan;
22(1):90.
PMID: 33494785
Background: New considerations during the ethical review processes may emerge from innovative, yet unfamiliar operational methods enabled in pragmatic randomized controlled trials (RCT), potentially making institutional review board (IRB) evaluation...
5.
Robertson H, Dinkova-Kostova A, Hayes J
Cancers (Basel)
. 2020 Dec;
12(12).
PMID: 33276631
NF-E2 p45-related factor 2 (NRF2, encoded in the human by ) mediates short-term adaptation to thiol-reactive stressors. In normal cells, activation of NRF2 by a thiol-reactive stressor helps prevent, for...
6.
Christodoulou E, Rashid M, Pacini C, Droop A, Robertson H, van Groningen T, et al.
Pigment Cell Melanoma Res
. 2020 Aug;
34(1):122-131.
PMID: 32767816
Targeting the MAPK signaling pathway has transformed the treatment of metastatic melanoma. CRISPR-Cas9 genetic screens provide a genome-wide approach to uncover novel genetic dependencies that might serve as therapeutic targets....
7.
Shi Q, Shambhu S, Marshall A, Rose-Kennedy E, Robertson H, Paullin M, et al.
Clin Trials
. 2020 Feb;
17(2):212-222.
PMID: 32009464
Aim: The purpose of this study is to evaluate HealthCore/Anthem Research Network recruitment strategies, compare response and enrollment rates for different recruitment strategies, and describe demographic and clinical characteristics of...
8.
Fishman E, Barron J, Dinh J, Jones W, Marshall A, Merkh R, et al.
Contemp Clin Trials Commun
. 2018 Nov;
12:154-160.
PMID: 30480162
Objective: Validate an algorithm that uses administrative claims data to identify eligible study subjects for the ADAPTABLE (Aspirin Dosing: A Patient-centric Trial Assessing Benefits and Long-Term Effectiveness) pragmatic clinical trial...
9.
Robertson H, Hayes J, Sutherland C
Biochem Pharmacol
. 2017 Nov;
147:77-92.
PMID: 29102676
Glycogen Synthase Kinase-3 (GSK3) was originally reported as a key enzyme of glucose homeostasis through regulation of the rate of glycogen synthesis. It has subsequently been found to influence most...
10.
Tebay L, Robertson H, Durant S, Vitale S, Penning T, Dinkova-Kostova A, et al.
Free Radic Biol Med
. 2015 Jul;
88(Pt B):108-146.
PMID: 26122708
Nad(p)h: quinone oxidoreductase-1 drug-metabolizing isoenzymes along with multidrug-resistance-associated efflux pumps. It therefore plays a pivotal role in both intrinsic resistance and cellular adaptation to reactive oxygen species (ROS) and xenobiotics....