Holly Mole
Overview
Explore the profile of Holly Mole including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
28
Followers
0
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Recent Articles
1.
Ash S, Orha R, Mole H, Dinesh-Kumar M, Lee S, Turrell F, et al.
J Immunother Cancer
. 2024 Feb;
12(2).
PMID: 38413223
Background: Targeting of solid cancers with chimeric antigen receptor (CAR)-T cells is limited by the lack of suitable tumor-specific antigens and the immunosuppressive, desmoplastic tumor microenvironment that impedes CAR-T cell...
2.
Wong C, Evangelou C, Sefton K, Leshem R, Zhang W, Gopalan V, et al.
Nat Commun
. 2023 Sep;
14(1):5983.
PMID: 37752135
Resistance mechanisms to immune checkpoint blockade therapy (ICBT) limit its response duration and magnitude. Paradoxically, Interferon γ (IFNγ), a key cytokine for cellular immunity, can promote ICBT resistance. Using syngeneic...
3.
Ginn L, Maltas J, Baker M, Chaturvedi A, Wilson L, Guilbert R, et al.
Proc Natl Acad Sci U S A
. 2023 Sep;
120(40):e2300489120.
PMID: 37748077
Lung cancer is the leading cause of cancer deaths. Its high mortality is associated with high metastatic potential. Here, we show that the RAC1-selective guanine nucleotide exchange factor T cell...
4.
Tuomela K, Mukherjee D, Ambrose A, Harikrishnan A, Mole H, Hurlstone A, et al.
Proc Natl Acad Sci U S A
. 2022 Jan;
119(3).
PMID: 35042775
The impact of radiotherapy on the interaction between immune cells and cancer cells is important not least because radiotherapy can be used alongside immunotherapy as a cancer treatment. Unexpectedly, we...
5.
Letrado P, Mole H, Montoya M, Palacios I, Barriuso J, Hurlstone A, et al.
Cancers (Basel)
. 2021 Aug;
13(15).
PMID: 34359605
Zebrafish embryo tumor transplant models are widely utilized in cancer research. Compared with traditional murine models, the small size and transparency of zebrafish embryos combined with large clutch sizes that...