Holly M Pugh
Overview
Explore the profile of Holly M Pugh including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
285
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0
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Recent Articles
1.
Schultheis K, Pugh H, Oh J, Nguyen J, Yung B, Reed C, et al.
Hum Vaccin Immunother
. 2020 Jun;
16(9):2165-2175.
PMID: 32544376
Respiratory Syncytial virus (RSV) is a major threat to many vulnerable populations. There are currently no approved vaccines, and RSV remains a high unmet global medical need. Here we describe...
2.
Schultheis K, Schaefer H, Pugh H, Yung B, Oh J, Nguyen J, et al.
J Vis Exp
. 2019 Feb;
(143).
PMID: 30735179
The guinea pig has played a pivotal role as a relevant small animal model in the development of vaccines for infectious diseases such as tuberculosis, influenza, diphtheria, and viral hemorrhagic...
3.
Cao Y, Rodgers D, Du J, Ahmad I, Hampton E, Ma J, et al.
Angew Chem Int Ed Engl
. 2016 May;
55(26):7520-4.
PMID: 27145250
Chimeric antigen receptor T (CAR-T) cells have demonstrated promising results against hematological malignancies, but have encountered significant challenges in translation to solid tumors. To overcome these hurdles, we have developed...
4.
Ma J, Kim J, Kazane S, Choi S, Yun H, Kim M, et al.
Proc Natl Acad Sci U S A
. 2016 Jan;
113(4):E450-8.
PMID: 26759368
The adoptive transfer of autologous T cells engineered to express a chimeric antigen receptor (CAR) has emerged as a promising cancer therapy. Despite impressive clinical efficacy, the general application of...
5.
Cao Y, Axup J, Ma J, Wang R, Choi S, Tardif V, et al.
Angew Chem Int Ed Engl
. 2015 Apr;
54(24):7022-7.
PMID: 25919418
Four different formats of bispecific antibodies (bsAbs) were generated that consist of anti-Her2 IgG or Fab site-specifically conjugated to anti-CD3 Fab using the genetically encoded noncanonical amino acid. These bsAbs...
6.
Kularatne S, Deshmukh V, Ma J, Tardif V, Lim R, Pugh H, et al.
Angew Chem Int Ed Engl
. 2014 Sep;
53(44):11863-7.
PMID: 25213874
A chemically defined anti-CXCR4-auristatin antibody-drug conjugate (ADC) was synthesized that selectively eliminates tumor cells overexpressing the CXCR4 receptor. The unnatural amino acid p-acetylphenylalanine (pAcF) was site-specifically incorporated into an anti-CXCR4...