Holger P Behrsing
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Explore the profile of Holger P Behrsing including associated specialties, affiliations and a list of published articles.
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9
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63
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Recent Articles
1.
Lehmann M, Krishnan R, Sucre J, Kulkarni H, Pineda R, Anderson C, et al.
Am J Respir Cell Mol Biol
. 2024 Nov;
PMID: 39499861
The urgent need for effective treatments for acute and chronic lung diseases underscores the significance of developing innovative preclinical human research tools. The 2023 ATS Workshop on Precision Cut Lung...
2.
Sharma M, Huber E, Arnesdotter E, Behrsing H, Bettmann A, Brandwein D, et al.
Arch Toxicol
. 2024 Oct;
99(1):57-66.
PMID: 39365315
Standard information reporting helps to ensure that assay conditions and data are consistently reported and to facilitate inter-laboratory comparisons. Here, we present recommendations on minimum information for reporting on the...
3.
Kim J, Schaible N, Hall J, Bartolak-Suki E, Deng Y, Herrmann J, et al.
Sci Adv
. 2023 May;
9(20):eadf2535.
PMID: 37205750
Emphysema is a debilitating disease that remodels the lung leading to reduced tissue stiffness. Thus, understanding emphysema progression requires assessing lung stiffness at both the tissue and alveolar scales. Here,...
4.
Patel V, Amin K, Wahab A, Marimoutou M, Ukishima L, Alvarez J, et al.
Toxicol Sci
. 2023 Jan;
191(2):253-265.
PMID: 36617185
Human precision-cut lung slices (hPCLS), considered a highly relevant ex vivo model of the lung, offer native architecture and cells of the lung tissue including respiratory parenchyma, small airways, and...
5.
Miller-Holt J, Behrsing H, Clippinger A, Hirn C, Stedeford T, Stucki A
Front Toxicol
. 2022 Sep;
4:943358.
PMID: 36157974
Regulatory frameworks on tobacco and other nicotine-containing products (TNCP) continue to evolve as novel products emerge, including electronic nicotine delivery systems (e.g., electronic cigarettes or vaping products), heated tobacco products,...
6.
Behrsing H, Wahab A, Ukishima L, Grodi C, Frentzel S, Johne S, et al.
Altern Lab Anim
. 2022 Aug;
50(4):293-309.
PMID: 35938181
The use of reconstituted human airway (RHuA) epithelial tissues to assess functional endpoints is highly relevant in respiratory toxicology, but standardised methods are lacking. In June 2015, the Institute for...
7.
Guo L, Hamre 3rd J, Eldridge S, Behrsing H, Cutuli F, Mussio J, et al.
Toxicol Sci
. 2017 Jan;
156(1):275-288.
PMID: 28115644
Chemotherapy-induced peripheral neuropathy (CIPN) is a major, dose-limiting adverse effect experienced by cancer patients. Advancements in mechanism-based risk mitigation and effective treatments for CIPN can be aided by suitable in...
8.
Behrsing H, Furniss M, Davis M, Tomaszewski J, Parchment R
Toxicol Sci
. 2012 Nov;
131(2):470-9.
PMID: 23143926
The anticancer drug (2-[4-amino-3-methylphenyl]-5-fluorobenzothiazole lysylamide dihydrochloride) (NSC 710305, Phortress) is a metabolically activated prodrug that causes DNA adduct formation and subsequent toxicity. Preclinically, it was found that hepatic, bone marrow,...
9.
Behrsing H, Vickers A, Tyson C
Biochem Biophys Res Commun
. 2003 Nov;
312(1):209-13.
PMID: 14630044
Precision-cut liver slices are reportedly limited as toxicity models by their short half-life in culture. We used traditional clinical chemistry biomarkers and histology to assess a newer procedure for improved...