Holger A Scheidt
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Explore the profile of Holger A Scheidt including associated specialties, affiliations and a list of published articles.
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92
Citations
1099
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Recent Articles
1.
Akkerman V, Reinholdt P, Schnoor-Madsen R, Lauritsen L, Bader J, Qian M, et al.
ACS Chem Neurosci
. 2024 Nov;
15(23):4322-4336.
PMID: 39574303
Allopregnanolone (AlloP) is an example of neuroactive steroids (NAS), which is a potent allosteric activator of the γ-aminobutyric acid A (GABA) receptor. The mechanisms underlying the biological activity of AlloP...
2.
Lehmann M, Halder S, Reinholdt P, Bashawat M, Scheidt H, Leopold J, et al.
Anal Chem
. 2024 Nov;
96(47):18596-18604.
PMID: 39537343
Live-cell imaging of cholesterol trafficking depends on suitable cholesterol analogs. However, existing fluorescent analogs of cholesterol either show very different physicochemical properties compared to cholesterol or demand excitation in the...
3.
To H, Reinholdt P, Bashawat M, Luck M, Lauritsen L, Akkerman V, et al.
Mol Cell Endocrinol
. 2024 Oct;
594:112385.
PMID: 39406287
Acyl-coenzyme A: cholesterol acyltransferases are enzymes which are involved in the homeostasis of cholesterol. Impaired enzyme activity is associated with the occurrence of various diseases like Alzheimer's disease, atherosclerosis, and...
4.
Kumar S, Kaur N, Hitaishi P, Ghosh S, Mithu V, Scheidt H
J Phys Chem B
. 2024 May;
128(22):5407-5418.
PMID: 38795045
In this work, we explored how the amount of cholesterol in the lipid membrane composed of phosphatidylcholine (POPC) or phosphatidylglycerol (POPG) affects the interaction with 1-dodecyl-3-methylimidazolium bromide ([CMIM]Br) ionic liquids...
5.
Scheidt H, Korn A, Schwarze B, Krueger M, Huster D
J Phys Chem B
. 2024 Feb;
128(7):1647-1655.
PMID: 38334278
Amyloid β (Aβ) is a hallmark protein of Alzheimer's disease. One physiologically important Aβ variant is formed by initial N-terminal truncation at a glutamic acid position (either E or E),...
6.
Fischer M, Luck M, Werle M, Vogel A, Bashawat M, Ludwig K, et al.
Chem Phys Lipids
. 2023 Oct;
257:105351.
PMID: 37863350
Ceritinib and imatinib are small-molecule protein kinase inhibitors which are applied as therapeutic agents against various diseases. The fundamentals of their clinical use, i.e. their pharmacokinetics as well as the...
7.
Akkerman V, Scheidt H, Reinholdt P, Bashawat M, Szomek M, Lehmann M, et al.
BBA Adv
. 2023 Sep;
4:100102.
PMID: 37691996
Natamycin is an antifungal polyene macrolide that is used as a food preservative but also to treat fungal keratitis and other yeast infections. In contrast to other polyene antimycotics, natamycin...
8.
Khodov I, Belov K, Huster D, Scheidt H
Membranes (Basel)
. 2023 Jun;
13(6).
PMID: 37367811
The present work analyzes the H NOESY MAS NMR spectra of three fenamates (mefenamic, tolfenamic, and flufenamic acids) localized in the lipid-water interface of phosphatidyloleoylphosphatidylcholine (POPC) membranes. The observed cross-peaks...
9.
Kaur N, Fischer M, Hitaishi P, Kumar S, Sharma V, Ghosh S, et al.
Langmuir
. 2022 Nov;
38(45):13803-13813.
PMID: 36321388
Ionic liquids based on doubly charged cations, often termed dicationic ionic liquids (DILs), offer robust physicochemical properties and low toxicity than conventional monocationic ionic liquids. In this design-based study, we...
10.
Bringas M, Luck M, Muller P, Scheidt H, Di Lella S
Membranes (Basel)
. 2022 Oct;
12(10).
PMID: 36295700
The structure and dynamics of membranes are crucial to ensure the proper functioning of cells. There are some compounds used in therapeutics that show nonspecific interactions with membranes in addition...