Hitoshi Kusakabe
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Explore the profile of Hitoshi Kusakabe including associated specialties, affiliations and a list of published articles.
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12
Citations
82
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Recent Articles
1.
Nishiyama T, Wada N, Kusakabe H, Ueda K
Methods Mol Biol
. 2024 Apr;
2798:195-203.
PMID: 38587744
Gamma-aminobutyric acid (GABA) is an amino acid that has a role as a signaling molecule. In plants, its involvement in stress responses is widely investigated. A newly developed method of...
2.
Yano Y, Matsuo S, Ito N, Tamura T, Kusakabe H, Inagaki K, et al.
Protein Sci
. 2021 Mar;
30(5):1044-1055.
PMID: 33764624
The alternation of substrate specificity expands the application range of enzymes in industrial, medical, and pharmaceutical fields. l-Glutamate oxidase (LGOX) from Streptomyces sp. X-119-6 catalyzes the oxidative deamination of l-glutamate...
3.
Kitagawa M, Ito N, Matsumoto Y, Saito M, Tamura T, Kusakabe H, et al.
J Struct Biol X
. 2021 Feb;
5:100044.
PMID: 33554108
Harmuful proteins are usually synthesized as inactive precursors and are activated by proteolytic processing. l-Amino acid oxidase (LAAO) is a flavoenzyme that catalyzes the oxidative deamination of l-amino acid to...
4.
Kondo H, Kitagawa M, Matsumoto Y, Saito M, Amano M, Sugiyama S, et al.
Protein Sci
. 2020 Sep;
29(11):2213-2225.
PMID: 32894626
l-Lysine oxidase (LysOX) is a FAD-dependent homodimeric enzyme that catalyzes the oxidative deamination of l-lysine to produce α-keto-ε-aminocaproate with ammonia and hydrogen peroxide. LysOX shows strict substrate specificity for l-lysine,...
5.
Nishiyama T, Sulistyaningdyah W, Ueda K, Kusakabe H
Biosci Biotechnol Biochem
. 2019 Sep;
84(1):118-125.
PMID: 31516066
We developed an enzymatic assay system enabling easy quantification of 4-aminobutyric acid (GABA). The reaction of GABA aminotransferase obtained from NBRC 13977 was combined to those of the previously developed...
6.
Amano M, Mizuguchi H, Sano T, Kondo H, Shinyashiki K, Inagaki J, et al.
J Biochem
. 2015 Feb;
157(6):549-59.
PMID: 25648943
L-Lysine α-oxidase (LysOX) from Trichoderma viride is a homodimeric 112 kDa flavoenzyme that catalyzes the oxidative deamination of L-lysine to form α-keto-ε-aminocaproate. LysOX severely inhibited growth of cancer cells but...
7.
Nishiyama T, Hashimoto Y, Kusakabe H, Kumano T, Kobayashi M
Proc Natl Acad Sci U S A
. 2014 Nov;
111(48):17152-7.
PMID: 25411318
Organocatalysts, low-molecular mass organic compounds composed of nonmetallic elements, are often used in organic synthesis, but there have been no reports of organocatalysts of biological origin that function in vivo....
8.
Utsumi T, Arima J, Sakaguchi C, Tamura T, Sasaki C, Kusakabe H, et al.
Biochem Biophys Res Commun
. 2011 Dec;
417(3):951-5.
PMID: 22197816
Recently, we have solved the crystal structure of L-glutamate oxidase (LGOX) from Streptomyces sp. X-119-6 (PDB code: 2E1M), the substrate specificity of which is strict toward L-glutamate. By a docking...
9.
Arima J, Sasaki C, Sakaguchi C, Mizuno H, Tamura T, Kashima A, et al.
FEBS J
. 2009 Jun;
276(14):3894-903.
PMID: 19531050
L-Glutamate oxidase (LGOX) from Streptomyces sp. X-119-6, which catalyzes the oxidative deamination of L-glutamate, has attracted increasing attention as a component of amperometric L-glutamate sensors used in the food industry...
10.
Ohgami N, Upadhyay S, Kabata A, Morimoto K, Kusakabe H, Suzuki H
Biosens Bioelectron
. 2006 Jul;
22(7):1330-6.
PMID: 16854580
A microfluidic system for the analysis of the activities of glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) was fabricated. The device consists of a glass chip with a micro-electrochemical L-glutamate...