Hiroyoshi Kunimoto
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Explore the profile of Hiroyoshi Kunimoto including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
358
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Recent Articles
11.
Soma S, Murakami K, Fukuchi Y, Kunimoto H, Nakajima H
Stem Cells
. 2023 Oct;
42(1):55-63.
PMID: 37813816
O-linked N-acetylglucosamine transferase (OGT) critically regulates wide variety of biological processes such as gene expression, metabolism, stress response, signaling and proteostasis. In adult hematopoiesis, OGT is crucial for differentiation of...
12.
Ohashi T, Takase-Minegishi K, Maeda A, Hamada N, Yoshimi R, Kirino Y, et al.
J Hematol
. 2023 May;
12(2):66-74.
PMID: 37187501
Background: Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy. ICI therapy is generally better tolerated than cytotoxic chemotherapy; however, hematological adverse events (AEs) have not been fully...
13.
Kunimoto H, Miura A, Maeda A, Tsuchida N, Uchiyama Y, Kunishita Y, et al.
Int J Hematol
. 2023 Apr;
118(4):494-502.
PMID: 37062784
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a new disease entity with autoinflammatory disorders (AID) driven by somatic variants in UBA1 that frequently co-exists with myelodysplastic syndromes (MDS)....
14.
Tanaka A, Nakano T, Nomura M, Yamazaki H, Bewersdorf J, Mulet-Lazaro R, et al.
Blood
. 2022 Jun;
140(8):875-888.
PMID: 35709354
Detailed genomic and epigenomic analyses of MECOM (the MDS1 and EVI1 complex locus) have revealed that inversion or translocation of chromosome 3 drives inv(3)/t(3;3) myeloid leukemias via structural rearrangement of...
15.
Teshigawara-Tanabe H, Hagihara M, Aoki J, Koyama S, Takahashi H, Nakajima Y, et al.
Hematology
. 2022 May;
27(1):620-628.
PMID: 35621915
: Allogeneic hematopoietic stem cell transplantation (allo-HCT) is the only curative treatment for myelodysplastic syndromes (MDS), although predicting post-transplant outcomes remains inconclusive. This study evaluated patients who underwent allo-HCT for...
16.
Sakamoto Y, Isono H, Enoki Y, Taguchi K, Miyazaki T, Kunimoto H, et al.
J Fungi (Basel)
. 2021 Nov;
7(11).
PMID: 34829262
We conducted population pharmacokinetic (PPK) analysis and Monte Carlo simulations to determine the appropriate prophylactic dose of fluconazole to prevent invasive candidiasis in patients with hematological malignancies. Patients receiving chemotherapy...
17.
Murakami K, Kurotaki D, Kawase W, Soma S, Fukuchi Y, Kunimoto H, et al.
Cell Rep
. 2021 Jan;
34(1):108579.
PMID: 33406421
O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) is a unique enzyme introducing O-GlcNAc moiety on target proteins, and it critically regulates various cellular processes in diverse cell types. However, its roles in...
18.
Kunimoto H, Fukuchi Y, Murakami K, Ikeda J, Teranaka H, Kato I, et al.
Hemasphere
. 2020 Nov;
4(5):e469.
PMID: 33163905
Acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) with both inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and monosomy 7 defines an extremely aggressive myeloid cancer whose molecular pathogenesis and optimal therapeutic strategy still remain unclear....
19.
Kunimoto H, Nakajima H
Cancer Sci
. 2020 Oct;
112(1):31-40.
PMID: 33048426
Regulation of genome-wide DNA methylation is fundamental for a variety of biological processes such as mammalian development, stem cell function, cellular proliferation/differentiation, and oncogenesis. Among the regulators of DNA methylation,...
20.
Kunimoto H, Nakajima H
Leuk Res
. 2020 Oct;
98:106457.
PMID: 33010619
Recent genomics studies have revealed that clonal hematopoietic expansion due to recurrent somatic mutations in hematopoietic cells are common in older people without evidence of hematological malignancies. This phenomenon, termed...