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Hiroto Takiguchi

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Citations 185
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Recent Articles
11.
Akata K, Leung J, Yamasaki K, Leitao Filho F, Yang J, Xi Yang C, et al.
J Infect Dis . 2021 Oct; 225(5):862-867. PMID: 34610114
Background: People with human immunodeficiency virus (PWH) have an increased risk of developing chronic obstructive pulmonary disease (COPD). Methods: We phenotyped lung macrophages in 4 subgroups-M1 (CD40+CD163-), M2 (CD40-CD163+), double...
12.
Nakano Y, Ichikawa T, Kobayashi H, Ishii M, Kameda S, Nakano E, et al.
Tokai J Exp Clin Med . 2021 Sep; 46(3):132-136. PMID: 34498249
We report a case of 71-year-old woman with lung cancer and high-attenuation ascites (HAA) due to iodine contrast material (ICM). The patient underwent two sequential CT scans at interval of...
13.
Leitao Filho F, Takiguchi H, Akata K, Ra S, Moon J, Kim H, et al.
Am J Respir Crit Care Med . 2021 Aug; 204(10):1143-1152. PMID: 34464242
Inhaled corticosteroids (ICS) are commonly prescribed with long-acting β-agonists (LABA) in chronic obstructive pulmonary disease (COPD). To date, the effects of ICS therapy on the airway microbiome in COPD are...
14.
Takiguchi H, Yang C, Yang C, Sahin B, Whalen B, Milne S, et al.
Sci Rep . 2021 Apr; 11(1):8282. PMID: 33859282
The classical M1/M2 polarity of macrophages may not be applicable to inflammatory lung diseases including chronic obstructive pulmonary disease (COPD) due to the complex microenvironment in lungs and the plasticity...
15.
Hayama N, Hattori S, Takahashi G, Takahashi F, Takeuchi T, Tanaka J, et al.
Tokai J Exp Clin Med . 2020 Dec; 45(4):224-229. PMID: 33300594
Objective: Malignant pleural effusions (MPEs) deteriorate the quality of life in patients with advanced stages of cancer. Although vascular endothelial growth factor (VEGF) is known to be a key factor...
16.
Akata K, Yamasaki K, Leitao Filho F, Xi Yang C, Takiguchi H, Sahin B, et al.
Biomedicines . 2020 Oct; 8(10). PMID: 33050042
Lung macrophages are the key immune effector cells in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD). Several studies have shown an increase in their numbers in bronchoalveolar lavage fluid...
17.
Takahashi M, Horio Y, Takihara T, Enokida K, Miyaoka M, Hirabayashi K, et al.
Intern Med . 2020 Oct; 60(4):617-621. PMID: 33028767
A 72-year-old man was treated with prednisolone and cyclosporine A for idiopathic pulmonary fibrosis. A nodule with a diameter of 19 mm was found in the right lung and diagnosed...
18.
Aoki T, Akiba T, Nishiyama J, Tajiri S, Hayama N, Takahashi G, et al.
Respir Res . 2019 Nov; 20(1):263. PMID: 31752884
Background: Although development of immune checkpoint inhibitors and various molecular target agents has extended overall survival time (OS) in advanced non-small cell lung cancer (NSCLC), a complete cure remains rare....
19.
Takiguchi H, Chen V, Obeidat M, Hollander Z, FitzGerald J, McManus B, et al.
Respir Res . 2019 Aug; 20(1):176. PMID: 31382977
Background: Effects of systemic corticosteroids on blood gene expression are largely unknown. This study determined gene expression signature associated with short-term oral prednisone therapy in patients with chronic obstructive pulmonary...
20.
Moon J, Leitao Filho F, Shahangian K, Takiguchi H, Sin D
Expert Rev Proteomics . 2018 Oct; 15(11):923-935. PMID: 30362838
Chronic obstructive pulmonary disease (COPD) is a heterogeneous set of disorders, characterized by airflow limitation, and reduced lung function. Despite increasing knowledge regarding its pathophysiology, there has been limited advancement...