Hirotada Kojima
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Explore the profile of Hirotada Kojima including associated specialties, affiliations and a list of published articles.
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14
Citations
429
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Recent Articles
1.
Wang L, Xiao S, Kunimoto H, Tokunaga K, Kojima H, Kimura M, et al.
Int J Mol Sci
. 2021 Oct;
22(19).
PMID: 34638866
RBM10 is an RNA-binding protein that regulates alternative splicing (AS). It localizes to the extra-nucleolar nucleoplasm and S1-1 nuclear bodies (NBs) in the nucleus. We investigated the biological significance of...
2.
Kunimoto H, Inoue A, Kojima H, Yang J, Zhao H, Tsuruta D, et al.
Genes Cells
. 2019 Dec;
25(2):100-110.
PMID: 31820547
RNA-binding motif protein 10 (RBM10) primarily regulates alternative splicing of certain genes. Loss-of-function mutations in RBM10 have been frequently reported in patients with various cancers. However, how RBM10 levels affect...
3.
Ohira T, Kojima H, Kuroda Y, Aoki S, Inaoka D, Osaki M, et al.
PLoS One
. 2019 Aug;
14(8):e0217605.
PMID: 31404068
Telomerase is a ribonucleoprotein ribonucleic enzyme that is essential for cellular immortalization via elongation of telomere repeat sequences at the end of chromosomes. Human telomerase reverse transcriptase (hTERT), the catalytic...
4.
Suematsu T, Li Y, Kojima H, Nakajima K, Oshimura M, Inoue T
Biochem Biophys Res Commun
. 2014 Oct;
453(3):588-94.
PMID: 25285631
Mitotic catastrophe, a form of cell death that occurs during mitosis and after mitotic slippage to a tetraploid state, plays an important role in the efficacy of cancer cell killing...
5.
Inoue T, Nakayama Y, Li Y, Matsumori H, Takahashi H, Kojima H, et al.
FEBS J
. 2014 Apr;
281(11):2623-37.
PMID: 24712640
Mitotic catastrophe, a form of cell death that occurs during mitosis and after mitotic slippage to a tetraploid state, plays important roles in the efficacy of cancer cell killing by...
6.
Kojima H, Inoue T, Kunimoto H, Nakajima K
JAKSTAT
. 2014 Jan;
2(4):e25763.
PMID: 24416650
Cytokines play several roles in developing and/or reinforcing premature cellular senescence of young cells. One such cytokine, interleukin-6 (IL-6), regulates senescence in some systems in addition to its known functions...
7.
Xiao S, Wang L, Kimura M, Kojima H, Kunimoto H, Nishiumi F, et al.
Biol Cell
. 2013 Jan;
105(4):162-74.
PMID: 23294349
Background Information: S1-1, also called RBM10, is an RNA-binding protein of 852 residues. An alteration of its activity causes TARP syndrome, a severe X-linked disorder with pre- or post-natal lethality...
8.
Kojima H, Kunimoto H, Inoue T, Nakajima K
Cell Cycle
. 2012 Mar;
11(4):730-9.
PMID: 22374671
Cells undergo senescence in response to various conditions, including telomere erosion, oncogene activation and multiple cytokines. One of these cytokines, interleukin-6 (IL‑6), not only functions in the immune system, but...
9.
Wakahara R, Kunimoto H, Tanino K, Kojima H, Inoue A, Shintaku H, et al.
Genes Cells
. 2012 Jan;
17(2):132-45.
PMID: 22233524
Signal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic transcription factor. It is activated by cytokines, including interleukin-6 (IL-6) through phosphorylation at Tyr705 (pY705), which is required...
10.
Li Y, Matsumori H, Nakayama Y, Osaki M, Kojima H, Kurimasa A, et al.
Genes Cells
. 2010 Nov;
16(1):34-45.
PMID: 21059157
We previously reported that sirtuin 2 (SIRT2), a mammalian member of the NAD+-dependent protein deacetylases, participates in mitotic regulation, specifically, in efficient mitotic cell death caused by the spindle checkpoint....