Hiroshi Tsugawa
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Explore the profile of Hiroshi Tsugawa including associated specialties, affiliations and a list of published articles.
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70
Citations
3643
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Recent Articles
1.
Takeda H, Matsuzawa Y, Takeuchi M, Takahashi M, Nishida K, Harayama T, et al.
Nat Commun
. 2024 Nov;
15(1):9903.
PMID: 39609386
Lipidomics and metabolomics communities comprise various informatics tools; however, software programs handling multimodal mass spectrometry (MS) data with structural annotations guided by the Lipidomics Standards Initiative are limited. Here, we...
2.
Sakamoto N, Oka T, Matsuzawa Y, Nishida K, Jayaprakash J, Hori A, et al.
Metabolites
. 2024 Nov;
14(11).
PMID: 39590838
: Untargeted lipidomics using collision-induced dissociation-based tandem mass spectrometry (CID-MS/MS) is essential for biological and clinical applications. However, annotation confidence still relies on manual curation by analytical chemists, despite the...
3.
Takeda H, Takeuchi M, Hasegawa M, Miyamoto J, Tsugawa H
Anal Chem
. 2024 Oct;
96(43):17065-17070.
PMID: 39410762
Lipid enrichment is indispensable for enhancing the coverage of targeted molecules in mass spectrometry (MS)-based lipidomics studies. In this study, we developed a simple stepwise fractionation method using a titanium-...
4.
Torta F, Hoffmann N, Burla B, Alecu I, Arita M, Bamba T, et al.
Nat Commun
. 2024 Oct;
15(1):8562.
PMID: 39362843
In this community effort, we compare measurements between 34 laboratories from 19 countries, utilizing mixtures of labelled authentic synthetic standards, to quantify by mass spectrometry four clinically used ceramide species...
5.
Mi-Ichi F, Tsugawa H, Vo T, Kurizaki Y, Yoshida H, Arita M
PLoS Pathog
. 2024 Aug;
20(8):e1012435.
PMID: 39172749
Entamoeba histolytica is a protozoan parasite belonging to the phylum Amoebozoa that causes amebiasis, a global public health problem. E. histolytica alternates its form between a proliferative trophozoite and a...
6.
Kiuchi S, Otoguro Y, Nitta T, Chung M, Nakaya T, Matsuzawa Y, et al.
J Am Soc Mass Spectrom
. 2024 Aug;
35(9):2118-2127.
PMID: 39136275
Capillary electrophoresis coupled with tandem mass spectrometry (CE-MS/MS) offers advantages in peak capacity and sensitivity for metabolic profiling owing to the electroosmotic flow-based separation. However, the utilization of data-independent MS/MS...
7.
Tsugawa H, Ishihara T, Ogasa K, Iwanami S, Hori A, Takahashi M, et al.
Nat Aging
. 2024 Apr;
4(5):709-726.
PMID: 38609525
Understanding the molecular mechanisms of aging is crucial for enhancing healthy longevity. We conducted untargeted lipidomics across 13 biological samples from mice at various life stages (2, 12, 19 and...
8.
Oka T, Matsuzawa Y, Tsuneyoshi M, Nakamura Y, Aoshima K, Tsugawa H
Sci Rep
. 2024 Apr;
14(1):6797.
PMID: 38565541
Alzheimer's disease (AD) is a neurodegenerative disease that commonly causes dementia. Identifying biomarkers for the early detection of AD is an emerging need, as brain dysfunction begins two decades before...
9.
Wang M, Tabeta H, Ohtaka K, Kuwahara A, Nishihama R, Ishikawa T, et al.
Commun Biol
. 2024 Jan;
7(1):102.
PMID: 38267515
Serine metabolism is involved in various biological processes. Here we investigate primary functions of the phosphorylated pathway of serine biosynthesis in a non-vascular plant Marchantia polymorpha by analyzing knockout mutants...
10.
Tokiyoshi K, Matsuzawa Y, Takahashi M, Takeda H, Hasegawa M, Miyamoto J, et al.
Anal Chem
. 2024 Jan;
96(3):991-996.
PMID: 38206184
Untargeted lipidomics using liquid chromatography (LC) coupled with tandem mass spectrometry (MS) is essential for large cohort studies. Using a fast LC gradient of less than 10 min for the...