Hiroshi Otani
Overview
Explore the profile of Hiroshi Otani including associated specialties, affiliations and a list of published articles.
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72
Citations
808
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Recent Articles
1.
Dinglasan J, Otani H, Doering D, Udwary D, Mouncey N
Nat Rev Microbiol
. 2025 Jan;
PMID: 39824928
Microbial secondary metabolites not only have key roles in microbial processes and relationships but are also valued in various sectors of today's economy, especially in human health and agriculture. The...
2.
Zdouc M, Blin K, Louwen N, Navarro J, Loureiro C, Bader C, et al.
Nucleic Acids Res
. 2024 Dec;
53(D1):D678-D690.
PMID: 39657789
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is...
3.
Toyama S, Ishikawa H, Abe A, Hao N, Otani H, Takamura S, et al.
Mod Rheumatol
. 2024 Oct;
PMID: 39470370
Objective: To elucidate the therapeutic effect of orthopedic surgical intervention (OSI) in difficult-to-treat rheumatoid arthritis (D2T RA) compared with non-D2T RA. Methods: A total of 534 recent surgeries were analyzed...
4.
Hao N, Ishikawa H, Abe A, Sudo M, Takamura S, Otani H, et al.
Mod Rheumatol
. 2024 Aug;
35(1):50-56.
PMID: 39116021
Objectives: The impact of osteoarthritis (OA) on the initial treatment response of rheumatoid arthritis (RA) by treat-to-target practice was compared between the patients with an onset age of ≥65 years...
5.
Otani H, Nakazato R, Koike K, Ohta K, Ikegami K
J Cell Sci
. 2024 Jul;
137(16).
PMID: 39056167
The primary cilium is a small organelle protruding from the cell surface that receives signals from the extracellular milieu. Although dozens of studies have reported that several genetic factors can...
6.
Funamura K, Ishikawa H, Abe A, Ito S, Otani H, Takamura S, et al.
J Orthop Sci
. 2023 Apr;
29(3):788-794.
PMID: 37012139
Background: In recent years, advances in pharmacotherapy for rheumatoid arthritis have dramatically improved the control of disease activity. However, a significant number of patients still develop hand deformity and require...
7.
Nakazato R, Otani H, Ijaz F, Ikegami K
Methods Cell Biol
. 2023 Mar;
175:45-68.
PMID: 36967145
Almost all cell types of mammals have a small protrusion named a primary cilium on their surface. Primary cilia are enriched by cilia-specific ion channels and G-protein-coupled receptors. They are...
8.
Kunakom S, Otani H, Udwary D, Doering D, Mouncey N
J Ind Microbiol Biotechnol
. 2023 Mar;
50(1).
PMID: 36931895
Summary: The presence of genes encoding P450s in gene clusters for ribosomally synthesized and post-translationally modified peptides expand structural and functional diversity of these secondary metabolites, and here, we review...
9.
Hasegawa E, Ito S, Kurosawa Y, Kobayashi D, Otani H, Abe A, et al.
Intern Med
. 2023 Feb;
62(3):373-379.
PMID: 36725065
Objective Sarcopenia is characterized by a loss of muscle mass and strength, which leads to frailty and mortality. Rheumatoid arthritis (RA) is considered to be a cause of sarcopenia. The...
10.
Otani H, Udwary D, Mouncey N
Sci Rep
. 2022 Nov;
12(1):18909.
PMID: 36344558
Streptomycetes are highly metabolically gifted bacteria with the abilities to produce bioproducts that have profound economic and societal importance. These bioproducts are produced by metabolic pathways including those for the...