Hiroshi Nishimasu
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Explore the profile of Hiroshi Nishimasu including associated specialties, affiliations and a list of published articles.
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84
Citations
6184
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Recent Articles
1.
Sawayama R, Minoda M, Kojima H, Okabe T, Isayama Y, Kato K, et al.
ACS Sens
. 2025 Feb;
10(2):664-670.
PMID: 39903855
We propose the design strategy of fluorogenic probes of proteases/peptidases and acylamino acid hydrolases utilizing an intramolecular O-to-N phosphoryl transfer reaction, in which the main chain of peptides or amino...
2.
Jiang K, Yan Z, Di Bernardo M, Sgrizzi S, Villiger L, Kayabolen A, et al.
Science
. 2024 Nov;
387(6732):eadr6006.
PMID: 39571002
Directed protein evolution is central to biomedical applications but faces challenges such as experimental complexity, inefficient multiproperty optimization, and local maxima traps. Although in silico methods that use protein language...
3.
Jiang K, Yan Z, Di Bernardo M, Sgrizzi S, Villiger L, Kayabolen A, et al.
bioRxiv
. 2024 Jul;
PMID: 39071429
Directed evolution of proteins is critical for applications in basic biological research, therapeutics, diagnostics, and sustainability. However, directed evolution methods are labor intensive, cannot efficiently optimize over multiple protein properties,...
4.
Nakane T, Nakagawa R, Ishiguro S, Okazaki S, Mori H, Shuto Y, et al.
Commun Biol
. 2024 Jul;
7(1):803.
PMID: 38961195
The RNA-guided DNA endonuclease Cas9 cleaves double-stranded DNA targets complementary to an RNA guide, and is widely used as a powerful genome-editing tool. Here, we report the crystal structure of...
5.
Acharya S, Ansari A, Das P, Hirano S, Aich M, Rauthan R, et al.
Nat Commun
. 2024 Jun;
15(1):5471.
PMID: 38942756
The clinical success of CRISPR therapies hinges on the safety and efficacy of Cas proteins. The Cas9 from Francisella novicida (FnCas9) is highly precise, with a negligible affinity for mismatched...
6.
Hiraizumi M, Perry N, Durrant M, Soma T, Nagahata N, Okazaki S, et al.
Nature
. 2024 Jun;
630(8018):994-1002.
PMID: 38926616
Insertion sequence (IS) elements are the simplest autonomous transposable elements found in prokaryotic genomes. We recently discovered that IS110 family elements encode a recombinase and a non-coding bridge RNA (bRNA)...
7.
Durrant M, Perry N, Pai J, Jangid A, Athukoralage J, Hiraizumi M, et al.
Nature
. 2024 Jun;
630(8018):984-993.
PMID: 38926615
Genomic rearrangements, encompassing mutational changes in the genome such as insertions, deletions or inversions, are essential for genetic diversity. These rearrangements are typically orchestrated by enzymes that are involved in...
8.
Schmitt-Ulms C, Kayabolen A, Manero-Carranza M, Zhou N, Donnelly K, Nuccio S, et al.
bioRxiv
. 2024 Feb;
PMID: 38352602
RNA editing offers the opportunity to introduce either stable or transient modifications to nucleic acid sequence without permanent off-target effects, but installation of arbitrary edits into the transcriptome is currently...
9.
Durrant M, Perry N, Pai J, Jangid A, Athukoralage J, Hiraizumi M, et al.
bioRxiv
. 2024 Feb;
PMID: 38328150
Genomic rearrangements, encompassing mutational changes in the genome such as insertions, deletions, or inversions, are essential for genetic diversity. These rearrangements are typically orchestrated by enzymes involved in fundamental DNA...
10.
Hiramoto T, Inaba H, Baatartsogt N, Kashiwakura Y, Hayakawa M, Kamoshita N, et al.
Blood Adv
. 2023 Oct;
7(22):7017-7027.
PMID: 37792826
The importance of genetic diagnosis for patients with hemophilia has been recently demonstrated. However, the pathological variant cannot be identified in some patients. Here, we aimed to identify the pathogenic...