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Hiroshi Isogai

Explore the profile of Hiroshi Isogai including associated specialties, affiliations and a list of published articles. Areas
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Articles 19
Citations 318
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Recent Articles
1.
Koyanagi Y, Suzuki R, Ihara K, Miyagi H, Isogai H, Yoneyama H, et al.
Pathog Dis . 2019 Jul; 77(4). PMID: 31344225
Susceptibility to enterohemorrhagic Escherichia coli (EHEC) infection varies among humans. The intestinal microbiota seems to play an essential role in host defense against EHEC; thus, we hypothesized that indigenous bacteria,...
2.
Saito K, Suzuki R, Koyanagi Y, Isogai H, Yoneyama H, Isogai E
Biomed Rep . 2019 Mar; 10(3):175-182. PMID: 30906546
Enterohemorrhagic (EHEC) O157:H7 has been known to cause outbreaks of hemorrhagic colitis and hemolytic uremic syndrome. We previously demonstrated that intestinal flora contribute to the prevention of EHEC infection in...
3.
Kuroda K, Fukuda T, Krstic-Demonacos M, Demonacos C, Okumura K, Isogai H, et al.
BMC Cancer . 2017 Jan; 17(1):33. PMID: 28061765
Background: Antimicrobial peptides (AMPs) play important roles in the innate immune system of all life forms and recently have been characterized as multifunctional peptides that have a variety of biological...
4.
Kuroda K, Okumura K, Isogai H, Isogai E
Front Oncol . 2015 Jul; 5:144. PMID: 26175965
Antimicrobial peptides (AMPs) play a critical role in innate host defense against microbial pathogens in many organisms. The human cathelicidin, LL-37, has a net positive charge and is amphiphilic, and...
5.
Kuroda K, Fukuda T, Isogai H, Okumura K, Krstic-Demonacos M, Isogai E
Int J Oncol . 2015 Feb; 46(4):1516-26. PMID: 25672949
Metabolic reprogramming is one of the hallmarks of cancer and can be targeted by therapeutic agents. We previously reported that cathelicidin-related or modified antimicrobial peptides, such as FF/CAP18, have antiproliferative...
6.
Kuroda K, Kiyono T, Eitsuka T, Isogai H, Takahashi K, Donai K, et al.
J Cell Biochem . 2014 Sep; 116(2):205-11. PMID: 25187009
Nonhuman primates are useful animal models for the study of human diseases. However, the number of established cell lines from nonhuman primates is quite limited compared with the number established...
7.
Takagi S, Nishimura J, Bai L, Miyagi H, Kuroda K, Hayashi S, et al.
Anim Sci J . 2013 Aug; 85(2):174-9. PMID: 23905845
A bovine myeloid antimicrobial peptide antimicrobial peptide (BMAP-28) is a member of the cathelicidin family and acts as a component of innate immunity. There are few reports of susceptibility difference...
8.
Kuroda K, Fukuda T, Okumura K, Yoneyama H, Isogai H, Savage P, et al.
Anticancer Drugs . 2013 Jul; 24(8):826-34. PMID: 23817390
Antimicrobial peptides of the cathelicidin family play a central role in the host defense system. Our group has reported previously that cathelicidin-related or cathelicidin-modified antimicrobial peptides, such as FF/CAP-18, have...
9.
Kuroda K, Fukuda T, Yoneyama H, Katayama M, Isogai H, Okumura K, et al.
Oncol Rep . 2012 Jun; 28(3):829-34. PMID: 22736062
Antimicrobial peptides of the cathelicidin family are found in many mammalian species, and are focused on various effects other than antimicrobial action. In this study, we evaluated the anti-proliferative effect...
10.
Takagi S, Hayashi S, Takahashi K, Isogai H, Bai L, Yoneyama H, et al.
Anim Sci J . 2012 Jun; 83(6):482-6. PMID: 22694332
A bovine myeloid antimicrobial peptide (BMAP-28) is a member of the cathelicidin family which is included in the innate immune system of mammals. Recently, there have been many studies about...