Hiroko Shimbo
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Explore the profile of Hiroko Shimbo including associated specialties, affiliations and a list of published articles.
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36
Citations
224
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Recent Articles
1.
Park J, Shimbo H, Tamura S, Tomoda T, Hikida T, Okado H, et al.
Behav Brain Res
. 2024 Oct;
476:115291.
PMID: 39401692
A combination of genetic predisposition and environmental factors contributes to the development of psychiatric disorders such as schizophrenia, bipolar disorder and major depressive disorder. Previous studies using mouse models suggested...
2.
Tanaka T, Hirai S, Manabe H, Endo K, Shimbo H, Nishito Y, et al.
J Neuroinflammation
. 2024 Oct;
21(1):260.
PMID: 39396010
Haploinsufficiency of the transcriptional repressor ZBTB18/RP58 is associated with intellectual disability. However, the mechanisms causing this disability are unknown, and preventative measures and treatments are not available. Here, we assessed...
3.
Hirai S, Sakuma A, Kunii Y, Shimbo H, Hino M, Izumi R, et al.
J Psychiatr Res
. 2023 May;
163:74-79.
PMID: 37207434
Schizophrenia (SZ) and bipolar disorder (BD), which are both psychiatric disorders, share some common clinical evidence. We recently discovered that brain capillary angiopathy is another common feature of these psychiatric...
4.
Hirai S, Miwa H, Shimbo H, Nakajima K, Kondo M, Tanaka T, et al.
Mol Psychiatry
. 2023 Jan;
28(6):2370-2381.
PMID: 36721027
ZBTB18/RP58 (OMIM *608433) is one of the pivotal genes responsible for 1q43q44 microdeletion syndrome (OMIM #612337) and its haploinsufficiency induces intellectual disability. However, the underlying pathological mechanism of ZBTB18/RP58 haploinsufficiency...
5.
Kojima K, Wada T, Shimbo H, Ikeda T, Jimbo E, Saitsu H, et al.
Hum Genome Var
. 2022 Sep;
9(1):33.
PMID: 36104326
The ATRX variant c.21-1G>A was detected by an exome analysis of a patient with Cockayne syndrome without alpha thalassemia X-linked intellectual disability syndrome (ATR-XS). In addition, variants in ERCC6 were...
6.
Hirai S, Miwa H, Tanaka T, Toriumi K, Kunii Y, Shimbo H, et al.
Sci Adv
. 2021 Nov;
7(46):eabl6077.
PMID: 34757783
Metabolic dysfunction is thought to contribute to the severity of psychiatric disorders; however, it has been unclear whether current high–simple sugar diets contribute to pathogenesis of these diseases. Here, we...
7.
Akiyama T, Hyodo Y, Hasegawa K, Oboshi T, Imai K, Ishihara N, et al.
Pediatr Neurol
. 2020 Sep;
113:33-41.
PMID: 32980745
Background: We aimed to demonstrate the biochemical characteristics of vitamin B6-dependent epilepsy, with a particular focus on pyridoxal 5'-phosphate and pyridoxal in the cerebrospinal fluid. Methods: Using our laboratory database,...
8.
Usui H, Tsurusaki Y, Shimbo H, Saitsu H, Harada N, Kitagawa N, et al.
Surg Today
. 2020 Sep;
51(3):439-446.
PMID: 32876734
Purpose: Tissue disaggregation and the cell sorting technique by surface markers has played an important role in isolating lymphatic endothelial cells (LECs) from lymphatic malformation (LM). However, this technique may...
9.
Uemura T, Ito S, Masuda T, Shimbo H, Goto T, Osaka H, et al.
Pharm Res
. 2020 Mar;
37(3):61.
PMID: 32124083
Purpose: Cyclocreatine, a creatine analog, is a candidate drug for treating patients with cerebral creatine deficiency syndromes (CCDSs) caused by creatine transporter (CRT, SLC6A8) deficiency, which reduces brain creatine level....
10.
Ichikawa K, Tsuyusaki Y, Shimbo H, Goto T
Pediatr Int
. 2019 Oct;
61(10):1055-1056.
PMID: 31625254
No abstract available.