Hiroki Shiwaku
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Explore the profile of Hiroki Shiwaku including associated specialties, affiliations and a list of published articles.
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32
Citations
373
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Recent Articles
1.
Toyoda S, Kikuchi M, Abe Y, Tashiro K, Handa T, Katayama S, et al.
EMBO Rep
. 2025 Jan;
26(4):948-981.
PMID: 39774335
Recent genetic studies by the Schizophrenia Exome Sequencing Meta-Analysis (SCHEMA) consortium have identified that protein-truncating variants of exportin 7 (XPO7) can increase the risk of schizophrenia (odds ratio, 28.1). Here...
2.
Tamura T, Takagi S, Hayakawa A, Oyama J, Fujino J, Shiwaku H, et al.
Front Psychiatry
. 2024 May;
15:1402695.
PMID: 38716114
Introduction: Acquired hepatocerebral degeneration (AHD) is a neurological condition associated with cerebral manganese (Mn) accumulation caused by portosystemic shunts (PSS), usually because of advanced liver disease. AHD is diagnosed by...
3.
Toyoda S, Handa T, Yong H, Takahashi H, Shiwaku H
Genes Cells
. 2023 Nov;
29(2):150-158.
PMID: 38009721
Inosine monophosphate dehydrogenase (IMPDH) is a rate-limiting enzyme in the de novo GTP biosynthesis pathway. Recent studies suggest that IMPDH2, an isoform of IMPDH, can localize to specific subcellular compartments...
4.
Matsuki H, Mandai S, Shiwaku H, Koide T, Takahashi N, Yanagi T, et al.
Aging (Albany NY)
. 2023 Oct;
15(20):10972-10995.
PMID: 37889501
Chronic kidney disease (CKD) causes cognitive impairment and contributes to the overall global burden of dementia. However, mechanisms through which the kidneys and brain communicate are not fully understood. We...
5.
Shiwaku H, Takahashi H
Brain Nerve
. 2023 Jun;
75(6):763-767.
PMID: 37287360
In the context of discovery of synaptic autoantibodies in patients with encephalitis, autoimmune psychosis with acute encephalopathy and psychosis as the main symptom has been proposed on the basis of...
6.
Shiwaku H, Katayama S, Gao M, Kondo K, Nakano Y, Motokawa Y, et al.
Brain Behav Immun
. 2023 Apr;
111:32-45.
PMID: 37004758
The molecular pathological mechanisms underlying schizophrenia remain unclear; however, genomic analysis has identified genes encoding important risk molecules. One such molecule is neurexin 1α (NRXN1α), a presynaptic cell adhesion molecule....
7.
Kubota M, Takahata K, Matsuoka K, Sano Y, Yamamoto Y, Tagai K, et al.
Schizophr Bull
. 2022 Dec;
49(3):688-696.
PMID: 36458958
Background And Hypothesis: Phosphodiesterase 10A (PDE10A) is a highly expressed enzyme in the basal ganglia, where cortical glutamatergic and midbrain dopaminergic inputs are integrated. Therapeutic PDE10A inhibition effects on schizophrenia...
8.
Tamura T, Sugihara G, Okita K, Mukai Y, Matsuda H, Shiwaku H, et al.
Transl Psychiatry
. 2022 Aug;
12(1):309.
PMID: 35922402
Dopamine dysfunction has been associated with depression. However, results of recent neuroimaging studies on dopamine transporter (DAT), which reflect the function of the dopaminergic system, are inconclusive. The aim of...
9.
Shiwaku H, Katayama S, Kondo K, Nakano Y, Tanaka H, Yoshioka Y, et al.
Cell Rep Med
. 2022 May;
3(4):100597.
PMID: 35492247
From genetic and etiological studies, autoimmune mechanisms underlying schizophrenia are suspected; however, the details remain unclear. In this study, we describe autoantibodies against neural cell adhesion molecule (NCAM1) in patients...
10.
Jin M, Shiwaku H, Tanaka H, Obita T, Ohuchi S, Yoshioka Y, et al.
Nat Commun
. 2021 Nov;
12(1):6565.
PMID: 34782623
Brain inflammation generally accompanies and accelerates neurodegeneration. Here we report a microglial mechanism in which polyglutamine binding protein 1 (PQBP1) senses extrinsic tau 3R/4R proteins by direct interaction and triggers...