Hiroki Hamada
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Explore the profile of Hiroki Hamada including associated specialties, affiliations and a list of published articles.
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92
Citations
490
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Recent Articles
1.
Kozai H, Watanabe C, Kosaka R, Aoki T, Hamada H, Kawashima M, et al.
Nutrients
. 2025 Jan;
16(24.
PMID: 39770998
Background: Cactus contains dietary fiber and minerals and is expected to have preventive effects against diabetes, arteriosclerosis, and other diseases. Additionally, cactus intake induces the production of short-chain fatty acids...
2.
Saitoh Y, Kanawa S, Nohara T, Yamaguchi R, Wakita A, Ikeda C, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2025 Jan;
PMID: 39751819
Natural stilbene compounds, such as resveratrol and pterostilbene, have been focused on owing to their diverse biological activities associated with antioxidant, anti-inflammatory, and anti-aging properties. However, their low water solubility...
3.
Nakayama T, Singh A, Fukutomi T, Uchida N, Terao Y, Hamada H, et al.
Cell Rep
. 2024 Apr;
43(4):114101.
PMID: 38613786
Syntaxin-1A (stx1a) repression causes a neurodevelopmental disorder phenotype, low latent inhibition (LI) behavior, by disrupting 5-hydroxytryptaminergic (5-HTergic) systems. Herein, we discovered that lysine acetyltransferase (KAT) 3B increases stx1a neuronal transcription...
4.
Watanabe C, Oyanagi E, Aoki T, Hamada H, Kawashima M, Yamagata T, et al.
Biosci Biotechnol Biochem
. 2023 Sep;
87(11):1407-1419.
PMID: 37667506
Although regular exercise has been reported to prevent depression, it has not been clarified whether the gut microbiota is involved in the factors that prevent depression through exercise. We investigated...
5.
Miura S, Oyanagi E, Watanabe C, Hamada H, Aoki T, Kremenik M, et al.
Biosci Biotechnol Biochem
. 2022 Aug;
86(10):1423-1430.
PMID: 35945649
Fatigue is accompanied by a decrease in physical activity or malaise, and might be reduced by acetyl-L-carnitine (ALC) administration. The purpose of this study was to investigate the preventive effects...
6.
Maharjan R, Fukuda Y, Nakayama T, Nakayama T, Hamada H, Ozaki S, et al.
Acta Crystallogr D Struct Biol
. 2022 Mar;
78(Pt 3):379-389.
PMID: 35234151
Capsaicinoids are phenolic compounds that have health benefits. However, the pungency and poor water solubility of these compounds limit their exploitation. Glycosylation is a powerful method to improve water solubility...
7.
Nakanishi I, Shoji Y, Ohkubo K, Ueno M, Shimoda K, Matsumoto K, et al.
Antioxidants (Basel)
. 2022 Feb;
11(2).
PMID: 35204222
Pterostilbene (PTS), a methylated analog of resveratrol (RSV), has recently attracted much attention due to its enhanced bioavailability compared to RSV. However, little is known about the radical-scavenging mechanism of...
8.
Shimoda K, Ono T, Hamada H
Biosci Biotechnol Biochem
. 2021 Feb;
85(1):103-107.
PMID: 33577646
The biotransformations of capsaicin and dihydrocapsaicin were investigated using cultured plant cells of Phytolacca americana as biocatalysts. Four products, ie 15-hydroxycapsaicin, dihydrocapsaicin, 15-hydroxydihydrocapsaicin, and capsaicin 4-β-glucoside, were isolated from the...
9.
Uchida N, Yanagi M, Hamada H
Nanomaterials (Basel)
. 2021 Feb;
11(2).
PMID: 33525364
A transdermal drug delivery system (TDDS) is a method that provides drug adsorption via the skin. TDDS could replace conventional oral administration and blood administration because it is easily accessible....
10.
Hosoda R, Hamada H, Uesugi D, Iwahara N, Nojima I, Horio Y, et al.
J Pharmacol Exp Ther
. 2020 Dec;
376(3):385-396.
PMID: 33335015
Resveratrol affords protection against reactive oxygen species (ROS)-related diseases via activation of SIRT1, an NAD-dependent deacetylase. However, the low bioavailability of resveratrol limits its therapeutic applications. Since piceatannol is a...