Hetty C M Sips
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Explore the profile of Hetty C M Sips including associated specialties, affiliations and a list of published articles.
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19
Citations
301
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Recent Articles
11.
van Weert L, Buurstede J, Sips H, Mol I, Puri T, Damsteegt R, et al.
Int J Mol Sci
. 2019 Apr;
20(7).
PMID: 30934833
Mineralocorticoid receptor (MR)-mediated signaling in the brain has been suggested as a protective factor in the development of psychopathology, in particular mood disorders. We recently identified genomic loci at which...
12.
Brinks J, van Dijk E, Habeeb M, Nikolaou A, Tsonaka R, Peters H, et al.
Invest Ophthalmol Vis Sci
. 2018 Nov;
59(13):5682-5692.
PMID: 30489628
Purpose: To isolate, culture, and characterize primary human choroidal endothelial cells, and to assess their responsiveness to corticosteroids, in order to enable knowledge gain on the pathogenesis of central serous...
13.
Koorneef L, van den Heuvel J, Kroon J, Boon M, t Hoen P, Hettne K, et al.
Endocrinology
. 2018 Oct;
159(12):3925-3936.
PMID: 30321321
Medication for nonalcoholic fatty liver disease (NAFLD) is an unmet need. Glucocorticoid (GC) stress hormones drive fat metabolism in the liver, but both full blockade and full stimulation of GC...
14.
Kroon J, Koorneef L, van den Heuvel J, Verzijl C, van de Velde N, Mol I, et al.
Endocrinology
. 2017 Sep;
159(1):535-546.
PMID: 28938459
Glucocorticoids influence a wide range of metabolic processes in the human body, and excessive glucocorticoid exposure is known to contribute to the development of metabolic disease. We evaluated the utility...
15.
van Weert L, Buurstede J, Mahfouz A, Braakhuis P, Polman J, Sips H, et al.
Endocrinology
. 2017 Mar;
158(5):1511-1522.
PMID: 28324065
In the limbic brain, mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) both function as receptors for the naturally occurring glucocorticoids (corticosterone/cortisol) but mediate distinct effects on cellular physiology via transcriptional...
16.
Mahfouz A, Lelieveldt B, Grefhorst A, van Weert L, Mol I, Sips H, et al.
Proc Natl Acad Sci U S A
. 2016 Jan;
113(10):2738-43.
PMID: 26811448
Steroid receptors are pleiotropic transcription factors that coordinate adaptation to different physiological states. An important target organ is the brain, but even though their effects are well studied in specific...
17.
Kooijman S, van den Berg R, Ramkisoensing A, Boon M, Kuipers E, Loef M, et al.
Proc Natl Acad Sci U S A
. 2015 May;
112(21):6748-53.
PMID: 25964318
Disruption of circadian rhythmicity is associated with obesity and related disorders, including type 2 diabetes and cardiovascular disease. Specifically, prolonged artificial light exposure associates with obesity in humans, although the...
18.
Boon M, Kooijman S, van Dam A, Pelgrom L, Berbee J, Visseren C, et al.
FASEB J
. 2014 Aug;
28(12):5361-75.
PMID: 25154875
The endocannabinoid system is an important player in energy metabolism by regulating appetite, lipolysis, and energy expenditure. Chronic blockade of the cannabinoid 1 receptor (CB1R) leads to long-term maintenance of...
19.
Abdulrahman R, Boon M, Sips H, Guigas B, Rensen P, Smit J, et al.
Thyroid
. 2013 Jul;
24(1):78-87.
PMID: 23819433
Background: Although adenosine monophosphate activated protein kinase (AMPK) plays a crucial role in energy metabolism, a direct effect of AMPK modulation on thyroid function has only recently been reported, and...