Hesham Nasser
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Explore the profile of Hesham Nasser including associated specialties, affiliations and a list of published articles.
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34
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1762
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Recent Articles
1.
Leong S, Nasser H, Ikeda T
Int J Mol Sci
. 2025 Feb;
26(4).
PMID: 40004025
The apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3/A3) family of cytosine deaminases serves as a key innate immune barrier against invading retroviruses and endogenous retroelements. The A3 family's...
2.
Takahashi N, Eltalkhawy Y, Nasu K, Abdelnaser R, Monde K, Habash S, et al.
Biochem Biophys Res Commun
. 2024 Jul;
729:150342.
PMID: 38981402
Despite viral suppression by effective combined antiretroviral therapy, HIV-1-infected individuals have an increased risk of non-AIDS-related overall morbidity, which is due to the persistent chronic inflammation exemplified by the activation...
3.
Tsujino S, Deguchi S, Nomai T, Padilla-Blanco M, Plianchaisuk A, Wang L, et al.
Microbiol Immunol
. 2024 Jul;
68(9):305-330.
PMID: 38961765
In middle to late 2023, a sublineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron XBB, EG.5.1 (a progeny of XBB.1.9.2), is spreading rapidly around the world. We performed...
4.
Fujita S, Plianchaisuk A, Deguchi S, Ito H, Nao N, Wang L, et al.
EBioMedicine
. 2024 Jun;
104:105181.
PMID: 38838469
Background: Although several SARS-CoV-2-related coronaviruses (SC2r-CoVs) were discovered in bats and pangolins, the differences in virological characteristics between SARS-CoV-2 and SC2r-CoVs remain poorly understood. Recently, BANAL-20-236 (B236) was isolated from...
5.
Tamura T, Irie T, Deguchi S, Yajima H, Tsuda M, Nasser H, et al.
Nat Commun
. 2024 Feb;
15(1):1176.
PMID: 38332154
Circulation of SARS-CoV-2 Omicron XBB has resulted in the emergence of XBB.1.5, a new Variant of Interest. Our phylogenetic analysis suggests that XBB.1.5 evolved from XBB.1 by acquiring the S486P...
6.
Tamura T, Mizuma K, Nasser H, Deguchi S, Padilla-Blanco M, Oda Y, et al.
Cell Host Microbe
. 2024 Jan;
32(2):170-180.e12.
PMID: 38280382
In late 2023, several SARS-CoV-2 XBB descendants, notably EG.5.1, were predominant worldwide. However, a distinct SARS-CoV-2 lineage, the BA.2.86 variant, also emerged. BA.2.86 is phylogenetically distinct from other Omicron sublineages,...
7.
Kimura I, Yamasoba D, Nasser H, Ito H, Zahradnik J, Wu J, et al.
J Virol
. 2023 Oct;
97(10):e0101123.
PMID: 37796123
Most studies investigating the characteristics of emerging SARS-CoV-2 variants have been focusing on mutations in the spike proteins that affect viral infectivity, fusogenicity, and pathogenicity. However, few studies have addressed...
8.
Ikeda T, Shimizu R, Nasser H, Carpenter M, Cheng A, Brown W, et al.
mBio
. 2023 Aug;
14(4):e0078223.
PMID: 37555667
HIV-1 must overcome multiple innate antiviral mechanisms to replicate in CD4 T lymphocytes and macrophages. Previous studies have demonstrated that the apolipoprotein B mRNA editing enzyme polypeptide-like 3 (APOBEC3, A3)...
9.
Tamura T, Ito J, Uriu K, Zahradnik J, Kida I, Anraku Y, et al.
Nat Commun
. 2023 May;
14(1):2800.
PMID: 37193706
In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified, and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that XBB emerged through the recombination of two...
10.
Ito J, Suzuki R, Uriu K, Itakura Y, Zahradnik J, Kimura K, et al.
Nat Commun
. 2023 May;
14(1):2671.
PMID: 37169744
In late 2022, various Omicron subvariants emerged and cocirculated worldwide. These variants convergently acquired amino acid substitutions at critical residues in the spike protein, including residues R346, K444, L452, N460,...