Herve J Schaffhauser
Overview
Explore the profile of Herve J Schaffhauser including associated specialties, affiliations and a list of published articles.
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3
Citations
191
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Recent Articles
1.
Gu G, Lorrain D, Wei H, Cole R, Zhang X, Daggett L, et al.
Brain Res
. 2008 Feb;
1197:47-62.
PMID: 18242587
The receptor localization of metabotropic glutamate receptors (mGlu) 2 and 3 was examined by using in situ hybridization and a well-characterized mGlu2-selective antibody in the rat forebrain. mGlu2 was highly...
2.
OBrien J, Lemaire W, Wittmann M, Jacobson M, Ha S, Wisnoski D, et al.
J Pharmacol Exp Ther
. 2004 Jan;
309(2):568-77.
PMID: 14747613
We found that N-[4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl]-2-hydroxybenzamide (CPPHA), is a potent and selective positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). CPPHA alone had no agonist activity and acted as...
3.
OBrien J, Lemaire W, Chen T, Chang R, Jacobson M, Ha S, et al.
Mol Pharmacol
. 2003 Aug;
64(3):731-40.
PMID: 12920211
We have identified a family of highly selective allosteric modulators of the group I metabotropic glutamate receptor subtype 5 (mGluR5). This family of closely related analogs exerts a spectrum of...