Herman Waldmann
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Explore the profile of Herman Waldmann including associated specialties, affiliations and a list of published articles.
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152
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Recent Articles
11.
Fuchs A, Gliwinski M, Grageda N, Spiering R, Abbas A, Appel S, et al.
Front Immunol
. 2018 Jan;
8:1844.
PMID: 29379498
Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of...
12.
Howie D, Ten Bokum A, Necula A, Cobbold S, Waldmann H
Front Immunol
. 2018 Jan;
8:1949.
PMID: 29375572
The differentiation and effector functions of both the innate and adaptive immune system are inextricably linked to cellular metabolism. The features of metabolism which affect both arms of the immune...
13.
Tsuda M, Tone Y, Ogawa C, Nagaoka Y, Katsumata M, Necula A, et al.
Front Immunol
. 2017 Mar;
8:279.
PMID: 28348568
The transcription factor FOXP3 plays key roles in the development and function of regulatory T cells (Treg) capable of preventing and correcting immunopathology. There has been much interest in exploiting...
14.
Besancon A, Baas M, Goncalves T, Valette F, Waldmann H, Chatenoud L, et al.
Front Immunol
. 2017 Mar;
8:218.
PMID: 28321218
Therapeutic tolerance to self-antigens or foreign antigens is thought to depend on constant vigilance by Foxp3 regulatory T cells (Tregs). Previous work using a pancreatic islet allograft model and a...
15.
Wallberg M, Recino A, Phillips J, Howie D, Vienne M, Paluch C, et al.
Immunology
. 2017 Feb;
151(2):248-260.
PMID: 28211040
T cells play a key role in the pathogenesis of type 1 diabetes, and targeting the CD3 component of the T-cell receptor complex provides one therapeutic approach. Anti-CD3 treatment can...
16.
Howie D, Cobbold S, Adams E, Ten Bokum A, Necula A, Zhang W, et al.
JCI Insight
. 2017 Feb;
2(3):e89160.
PMID: 28194435
Tregs can adopt a catabolic metabolic program with increased capacity for fatty acid oxidation-fueled oxidative phosphorylation (OXPHOS). It is unclear why this form of metabolism is favored in Tregs and,...
17.
Sun B, Banugaria S, Prater S, Patel T, Fredrickson K, Ringler D, et al.
Mol Genet Metab Rep
. 2016 Nov;
1:446-450.
PMID: 27896120
Approximately 35-40% of patients with classic infantile Pompe disease treated with enzyme replacement therapy (ERT) develop high, sustained antibody titers against the therapeutic enzyme alglucosidase alfa, which abrogates the treatment...
18.
Waldmann H, Howie D, Cobbold S
Microbiol Spectr
. 2016 Oct;
4(4).
PMID: 27726804
A major goal of immunosuppressive therapies is to harness immune tolerance mechanisms so as to minimize unwanted side effects associated with protracted immunosuppressive therapy. Antibody blockade of lymphocyte coreceptor and...
19.
Hotta R, Ohira M, Matsuura T, Muraoka I, Tryphonopoulos P, Fan J, et al.
PLoS One
. 2016 Aug;
11(8):e0161618.
PMID: 27560943
Background: T-cell depleting strategies have become an integral part of immunosuppressive regimens in organ transplantation. Alemtuzumab is a humanized monoclonal antibody against CD52, a cell-surface antigen on several immune cells....
20.
Hilbrands R, Chen Y, Kendal A, Adams E, Cobbold S, Waldmann H, et al.
Front Immunol
. 2016 May;
7:124.
PMID: 27148253
Regulatory T cells expressing the transcription factor Foxp3 require acquisition of a specific hypomethylation pattern to ensure optimal functional commitment, limited lineage plasticity, and long-term maintenance of tolerance. A better...