Henry T Hsueh
Overview
Explore the profile of Henry T Hsueh including associated specialties, affiliations and a list of published articles.
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10
Citations
111
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Recent Articles
1.
Shapiro R, Bockley K, Hsueh H, Appell M, Carter D, Ortiz J, et al.
J Control Release
. 2024 May;
371:101-110.
PMID: 38782065
Vaginal drug delivery is often preferred over systemic delivery to reduce side effects and increase efficacy in treating diseases and conditions of the female reproductive tract (FRT). Current vaginal products...
2.
Hsueh H, Chou R, Rai U, Kolodziejski P, Liyanage W, Pejavar J, et al.
J Control Release
. 2023 Sep;
362:371-380.
PMID: 37657693
Effective eye drop delivery systems for treating diseases of the posterior segment have yet to be clinically validated. Further, adherence to eye drop regimens is often problematic due to the...
3.
Hsueh H, Chou R, Rai U, Liyanage W, Kim Y, Appell M, et al.
Nat Commun
. 2023 May;
14(1):2509.
PMID: 37130851
Sustained drug delivery strategies have many potential benefits for treating a range of diseases, particularly chronic diseases that require treatment for years. For many chronic ocular diseases, patient adherence to...
4.
Kanan Y, Hackett S, Hsueh H, Khan M, Ensign L, Campochiaro P
Free Radic Biol Med
. 2023 Feb;
198:118-122.
PMID: 36736930
Retinitis pigmentosa (RP) is caused by many different mutations that promote the degeneration of rod photoreceptors and have no direct effect on cones. After the majority of rods have died...
5.
Li L, Shapiro R, Joo M, Josyula A, Hsueh H, Gutierrez O, et al.
Gastroenterology
. 2023 Jan;
164(6):937-952.e13.
PMID: 36657529
Background & Aims: Tissue fibrosis results from uncontrolled healing responses leading to excessive mesenchymal cell activation and collagen and other extracellular matrix deposition. In the gastrointestinal tract, fibrosis leads to...
6.
Hsueh H, Kim Y, Pitha I, Shin M, Berlinicke C, Chou R, et al.
Pharmaceutics
. 2021 Jun;
13(5).
PMID: 34062883
Glaucoma is the leading cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP) is one of the major risk factors for glaucoma onset and progression, and available pharmaceutical interventions are...
7.
Kim Y, Hsueh H, Shin M, Berlinicke C, Han H, Anders N, et al.
Drug Deliv Transl Res
. 2021 Apr;
12(4):826-837.
PMID: 33900546
While eye drops are the most common ocular dosage form, eye drops for treating diseases of the posterior segment (retina, choroid, optic nerve) have yet to be developed. In glaucoma,...
8.
Kim Y, Hsueh H, Kim N, Rodriguez J, Leo K, Rao D, et al.
Adv Ther (Weinh)
. 2021 Mar;
4(2).
PMID: 33709020
We here introduce a new paradigm to promote pulmonary DNA vaccination. Specifically, we demonstrate that nanoparticles designed to rapidly penetrate airway mucus (mucus-penetrating particle or MPP) enhance the delivery of...
9.
Zierden H, Josyula A, Shapiro R, Hsueh H, Hanes J, Ensign L
Trends Mol Med
. 2021 Jan;
27(5):436-450.
PMID: 33414070
The efficacy of drugs administered by traditional routes is limited by numerous biological barriers that preclude reaching the intended site of action. Further, full body systemic exposure leads to dose-limiting,...
10.
Kim Y, Shin M, Hackett S, Hsueh H, Lima E Silva R, Date A, et al.
Nat Biomed Eng
. 2020 Sep;
4(11):1053-1062.
PMID: 32895514
Eye-drop formulations should hold as high a concentration of soluble drug in contact with ocular epithelium for as long as possible. However, eye tears and frequent blinking limit drug retention...