Henry Brinkerhoff
Overview
Explore the profile of Henry Brinkerhoff including associated specialties, affiliations and a list of published articles.
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15
Citations
648
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Recent Articles
1.
Chen X, van de Sande J, Ritmejeris J, Wen C, Brinkerhoff H, Laszlo A, et al.
ACS Nano
. 2024 Oct;
18(42):28999-29007.
PMID: 39388343
Peptide hormones are decorated with post-translational modifications (PTMs) that are crucial for receptor recognition. Tyrosine sulfation on plant peptide hormones is, for example, essential for plant growth and development. Measuring...
2.
Nova I, Craig J, Mazumder A, Laszlo A, Derrington I, Noakes M, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(29):e2321017121.
PMID: 38990947
RNA polymerases (RNAPs) carry out the first step in the central dogma of molecular biology by transcribing DNA into RNA. Despite their importance, much about how RNAPs work remains unclear,...
3.
Smith D, Thomas C, Craig J, Brinkerhoff H, Abell S, Franzi M, et al.
Nucleic Acids Res
. 2024 Jun;
52(13):7429-7436.
PMID: 38884270
Nanopores are increasingly powerful tools for single molecule sensing, in particular, for sequencing DNA, RNA and peptides. This success has spurred efforts to sequence non-canonical nucleic acid bases and amino...
4.
Chen X, van de Sande J, Ritmejeris J, Wen C, Brinkerhoff H, Laszlo A, et al.
bioRxiv
. 2024 May;
PMID: 38765996
Peptide phytohormones are decorated with post-translational modifications (PTMs) that are crucial for receptor recognition. Tyrosine sulfation on these hormones is essential for plant growth and development1. Measuring the occurrence and...
5.
Marx S, Mickolajczyk K, Craig J, Thomas C, Pfeffer A, Abell S, et al.
Nucleic Acids Res
. 2023 Aug;
51(17):9266-9278.
PMID: 37560916
The genome of SARS-CoV-2 encodes for a helicase (nsp13) that is essential for viral replication and highly conserved across related viruses, making it an attractive antiviral target. Here we use...
6.
Nova I, Ritmejeris J, Brinkerhoff H, Koenig T, Gundlach J, Dekker C
Nat Biotechnol
. 2023 Jun;
42(5):710-714.
PMID: 37386295
Current methods to detect post-translational modifications of proteins, such as phosphate groups, cannot measure single molecules or differentiate between closely spaced phosphorylation sites. We detect post-translational modifications at the single-molecule...
7.
Thomas C, Craig J, Hoshika S, Brinkerhoff H, Huang J, Abell S, et al.
J Am Chem Soc
. 2023 Apr;
PMID: 37036666
Chemists have now synthesized new kinds of DNA that add nucleotides to the four standard nucleotides (guanine, adenine, cytosine, and thymine) found in standard Terran DNA. Such "artificially expanded genetic...
8.
Brinkerhoff H, Kang A, Liu J, Aksimentiev A, Dekker C
Science
. 2021 Nov;
374(6574):1509-1513.
PMID: 34735217
A proteomics tool capable of identifying single proteins would be important for cell biology research and applications. Here, we demonstrate a nanopore-based single-molecule peptide reader sensitive to single–amino acid substitutions...
9.
Noakes M, Brinkerhoff H, Laszlo A, Derrington I, Langford K, Mount J, et al.
Nat Biotechnol
. 2019 Apr;
37(6):651-656.
PMID: 31011178
Nanopore DNA sequencing is limited by low base-calling accuracy. Improved base-calling accuracy has so far relied on specialized base-calling algorithms, different nanopores and motor enzymes, or biochemical methods to re-read...
10.
Craig J, Laszlo A, Nova I, Brinkerhoff H, Noakes M, Baker K, et al.
Nucleic Acids Res
. 2019 Jan;
47(5):2506-2513.
PMID: 30649515
Motor enzymes that process nucleic-acid substrates play vital roles in all aspects of genome replication, expression, and repair. The DNA and RNA nucleobases are known to affect the kinetics of...