Helmut Unruh
Overview
Explore the profile of Helmut Unruh including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
847
Followers
0
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Recent Articles
1.
Ghavami S, Yeganeh B, Zeki A, Shojaei S, Kenyon N, Ott S, et al.
Am J Physiol Lung Cell Mol Physiol
. 2017 Oct;
314(3):L493-L504.
PMID: 29074489
Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease in adults with limited treatment options. Autophagy and the unfolded protein response (UPR), fundamental processes induced by cell stress, are...
2.
Anaparti V, Pascoe C, Jha A, Mahood T, Ilarraza R, Unruh H, et al.
Am J Physiol Lung Cell Mol Physiol
. 2016 Jul;
311(2):L467-80.
PMID: 27371735
We have shown that N-methyl-d-aspartate receptors (NMDA-Rs) are receptor-operated calcium entry channels in human airway smooth muscle (HASM) during contraction. Tumor necrosis factor (TNF) augments smooth muscle contractility by influencing...
3.
Ojo O, Ryu M, Jha A, Unruh H, Halayko A
Am J Physiol Lung Cell Mol Physiol
. 2015 Oct;
309(11):L1354-66.
PMID: 26432865
High mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) protein that binds Toll-like receptors (e.g., TLR4) and the receptor for advanced glycated end products (RAGE). The direct...
4.
Anaparti V, Ilarraza R, Orihara K, Stelmack G, Ojo O, Mahood T, et al.
Am J Physiol Lung Cell Mol Physiol
. 2015 Apr;
308(12):L1253-64.
PMID: 25888577
Human airway smooth muscle (HASM) exhibits enhanced contractility in asthma. Inflammation is associated with airway hypercontractility, but factors that underpin these features are not fully elucidated. Glutamate toxicity associated with...
5.
Sharma P, Jha A, Stelmack G, Detillieux K, Basu S, Klonisch T, et al.
Can J Physiol Pharmacol
. 2015 Feb;
93(3):195-202.
PMID: 25692961
The dystrophin-glycoprotein complex (DGC) is an integral part of caveolae microdomains, and its interaction with caveolin-1 is essential for the phenotype and functional properties of airway smooth muscle (ASM). The...
6.
Ghavami S, Sharma P, Yeganeh B, Ojo O, Jha A, Mutawe M, et al.
Biochim Biophys Acta
. 2014 Mar;
1843(7):1259-71.
PMID: 24637330
HMG-CoA reductase, the proximal rate-limiting enzyme in the mevalonate pathway, is inhibited by statins. Beyond their cholesterol lowering impact, statins have pleiotropic effects and their use is linked to improved...
7.
Tran T, Teoh C, Tam J, Qiao Y, Chin C, Chong O, et al.
FASEB J
. 2013 Jun;
27(10):3991-4003.
PMID: 23756649
Increased airway smooth muscle (ASM) mass is believed to underlie the relatively fixed airway hyperresponsiveness (AHR) in asthma. Developments of therapeutic approaches to reverse airway remodeling are impeded by our...
8.
Ghavami S, Mutawe M, Schaafsma D, Yeganeh B, Unruh H, Klonisch T, et al.
Am J Physiol Lung Cell Mol Physiol
. 2011 Dec;
302(4):L420-8.
PMID: 22160308
Geranylgeranyl transferase 1 (GGT1) is involved in the posttranslational prenylation of signaling proteins, such as small GTPases. We have shown that blocking the formation of isoprenoids with statins regulates survival...
9.
Algurashi F, Ong B, Unruh H
J Clin Anesth
. 2011 Nov;
23(7):594-6.
PMID: 22050814
No abstract available.
10.
Schaafsma D, McNeill K, Mutawe M, Ghavami S, Unruh H, Jacques E, et al.
Respir Res
. 2011 Aug;
12:113.
PMID: 21864337
Background: Bronchial fibroblasts contribute to airway remodelling, including airway wall fibrosis. Transforming growth factor (TGF)-β1 plays a major role in this process. We previously revealed the importance of the mevalonate...