Hellen Ishikawa-Ankerhold
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Explore the profile of Hellen Ishikawa-Ankerhold including associated specialties, affiliations and a list of published articles.
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38
Citations
567
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Recent Articles
1.
Papargyriou A, Najajreh M, Cook D, Maurer C, Barthel S, Messal H, et al.
Nat Biomed Eng
. 2024 Dec;
PMID: 39658630
In patients with pancreatic ductal adenocarcinoma (PDAC), intratumoural and intertumoural heterogeneity increases chemoresistance and mortality rates. However, such morphological and phenotypic diversities are not typically captured by organoid models of...
2.
PD-1 blockade does not improve efficacy of EpCAM-directed CAR T-cell in lung cancer brain metastasis
Blobner J, Dengler L, Eberle C, Herold J, Xu T, Beck A, et al.
Cancer Immunol Immunother
. 2024 Oct;
73(12):255.
PMID: 39358663
Background: Lung cancer brain metastasis has a devastating prognosis, necessitating innovative treatment strategies. While chimeric antigen receptor (CAR) T-cell show promise in hematologic malignancies, their efficacy in solid tumors, including...
3.
Ishikawa-Ankerhold H, Busch B, Bader A, Maier-Begandt D, Dionisio F, Namineni S, et al.
PLoS Pathog
. 2024 Sep;
20(9):e1012580.
PMID: 39348445
Helicobacter pylori (H. pylori) is a bacterial pathogen that exclusively colonizes the human gastric mucosa and can cause persistent infection. In this process, H. pylori employs various strategies to avoid...
4.
Wang X, Campbell B, Bodogai M, McDevitt R, Patrikeev A, Gusev F, et al.
Brain Behav Immun
. 2024 Aug;
122:444-455.
PMID: 39191349
Alzheimer's disease (AD) is linked to toxic Aβ plaques in the brain and activation of innate responses. Recent findings however suggest that the disease may also depend on the adaptive...
5.
Gaertner F, Ishikawa-Ankerhold H, Stutte S, Fu W, Weitz J, Dueck A, et al.
Nature
. 2024 Jul;
631(8021):645-653.
PMID: 38987596
Platelet homeostasis is essential for vascular integrity and immune defence. Although the process of platelet formation by fragmenting megakaryocytes (MKs; thrombopoiesis) has been extensively studied, the cellular and molecular mechanisms...
6.
Mueller T, Pilartz M, Thakur M, LangHeinrich T, Luo J, Block R, et al.
Haematologica
. 2024 Apr;
109(8):2487-2499.
PMID: 38572559
Innate myeloid cells especially neutrophils and their extracellular traps are known to promote intravascular coagulation and thrombosis formation in infections and various other conditions. Innate myeloid cell-dependent fibrin formation can...
7.
Liu H, Ishikawa-Ankerhold H, Winterhalter J, Lorenz M, Vladymyrov M, Massberg S, et al.
Cells
. 2023 Oct;
12(19).
PMID: 37830625
Platelets are generated by specialized cells called megakaryocytes (MKs). However, MK's origin and platelet release mode have remained incompletely understood. Here, we established direct visualization of embryonic thrombopoiesis in vivo...
8.
Xu T, Karschnia P, Cadilha B, Dede S, Lorenz M, Seewaldt N, et al.
Oncoimmunology
. 2023 Jan;
12(1):2163781.
PMID: 36687005
Lung cancer patients are at risk for brain metastases and often succumb to their intracranial disease. Chimeric Antigen Receptor (CAR) T-cells emerged as a powerful cell-based immunotherapy for hematological malignancies;...
9.
Neutrophil "plucking" on megakaryocytes drives platelet production and boosts cardiovascular disease
Petzold T, Zhang Z, Ballesteros I, Saleh I, Polzin A, Thienel M, et al.
Immunity
. 2022 Oct;
55(12):2285-2299.e7.
PMID: 36272416
Intravascular neutrophils and platelets collaborate in maintaining host integrity, but their interaction can also trigger thrombotic complications. We report here that cooperation between neutrophil and platelet lineages extends to the...
10.
Ishikawa-Ankerhold H, Kroll J, van den Heuvel D, Renkawitz J, Muller-Taubenberger A
Cells
. 2022 Jun;
11(11).
PMID: 35681473
Directional cell migration and the establishment of polarity play an important role in development, wound healing, and host cell defense. While actin polymerization provides the driving force at the cell...