Helena Westerdahl
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Explore the profile of Helena Westerdahl including associated specialties, affiliations and a list of published articles.
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59
Citations
1381
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Recent Articles
1.
Ruesink-Bueno I, Drews A, OConnor E, Westerdahl H
Genome Biol Evol
. 2024 Oct;
16(11).
PMID: 39462092
The major histocompatibility complex (MHC) is central in adaptive immunity, with the highly polymorphic MHC genes encoding antigen-presenting molecules. Two MHC class II (MHC-II) loci, DA1 and DA2, predate the...
2.
Watson H, Drews A, Skogsmyr K, Neto J, Roved J, Westerdahl H
Proc Biol Sci
. 2024 Feb;
291(2017):20232857.
PMID: 38378156
The exceptional polymorphism observed within genes of the major histocompatibility complex (MHC), a core component of the vertebrate immune system, has long fascinated biologists. The highly polymorphic MHC class-I (MHC-I)...
3.
Eltschkner S, Mellinger S, Buus S, Nielsen M, Paulsson K, Lindkvist-Petersson K, et al.
Front Immunol
. 2023 Jul;
14:1209059.
PMID: 37483599
Long-distance migratory animals such as birds and bats have evolved to withstand selection imposed by pathogens across the globe, and pathogen richness is known to be particularly high in tropical...
4.
Mellinger S, Stervander M, Lundberg M, Drews A, Westerdahl H
PeerJ
. 2023 Jul;
11:e15480.
PMID: 37456901
Long-read sequencing offers a great improvement in the assembly of complex genomic regions, such as the major histocompatibility complex (MHC) region, which can contain both tandemly duplicated MHC genes (paralogs)...
5.
Vinkler M, Fiddaman S, Tesicky M, OConnor E, Savage A, Lenz T, et al.
J Evol Biol
. 2023 May;
36(6):847-873.
PMID: 37255207
Driven by co-evolution with pathogens, host immunity continuously adapts to optimize defence against pathogens within a given environment. Recent advances in genetics, genomics and transcriptomics have enabled a more detailed...
6.
Raberg L, Clough D, Hagstrom A, Scherman K, Andersson M, Drews A, et al.
Evolution
. 2022 Aug;
76(9):2067-2075.
PMID: 35909235
MHC genes are extraordinarily polymorphic in most taxa. Host-pathogen coevolution driven by negative frequency-dependent selection (NFDS) is one of the main hypotheses for the maintenance of such immunogenetic variation. Here,...
7.
Garcia-Longoria L, Magallanes S, Huang X, Drews A, Raberg L, Marzal A, et al.
BMC Ecol Evol
. 2022 Jun;
22(1):73.
PMID: 35655150
Background: Hosts are often simultaneously infected with several parasite species. These co-infections can lead to within-host interactions of parasites, including mutualism and competition, which may affect both virulence and transmission....
8.
Roved J, Hansson B, Stervander M, Hasselquist D, Westerdahl H
Mol Ecol Resour
. 2022 May;
22(7):2775-2792.
PMID: 35587892
The major histocompatibility complex (MHC) plays a central role in the vertebrate adaptive immune system and has been of long-term interest in evolutionary biology. While several protocols have been developed...
9.
Westerdahl H, Mellinger S, Sigeman H, Kutschera V, Proux-Wera E, Lundberg M, et al.
Mol Ecol Resour
. 2022 Mar;
22(6):2379-2395.
PMID: 35348299
The major histocompatibility complex (MHC) is of central importance to the immune system, and an optimal MHC diversity is believed to maximize pathogen elimination. Birds show substantial variation in MHC...
10.
Sigeman H, Strandh M, Proux-Wera E, Kutschera V, Ponnikas S, Zhang H, et al.
Mol Biol Evol
. 2021 Sep;
38(12):5275-5291.
PMID: 34542640
How the avian sex chromosomes first evolved from autosomes remains elusive as 100 million years (My) of divergence and degeneration obscure their evolutionary history. The Sylvioidea group of songbirds is...