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Helena Cristobal

Explore the profile of Helena Cristobal including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 102
Followers 0
Related Specialties
Biomedical Engineering
General Medicine
Gastroenterology
Top 10 Co-Authors
Pablo Garcia de Frutos
Albert Morales
Jose Tomas Ortiz-Perez
Anna Tutusaus
Jose T Ortiz-Perez
Montserrat Batlle
Manel Sabate
Montserrat Mari
Xavier Bosch
Rosario J Perea
Published In
Eur Heart J Acute Cardiovasc Care
Biomedicines
J Pers Med
PLoS One
EBioMedicine
Affiliations
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Recent Articles
1.
Prognostic Value of Soluble AXL in Serum from Heart Failure Patients with Preserved and Reduced Left Ventricular Ejection Fraction
Cristobal H, Enjuanes C, Batlle M, Tajes M, Campos B, Francesch J, et al.
J Pers Med . 2023 Mar; 13(3). PMID: 36983628
Heart failure (HF) is classified according to the degree of reduction in left ventricular ejection fraction (EF) in HF with reduced, mildly reduced, and preserved EF. Biomarkers could behave differently...
2.
Direct actions of dapagliflozin and interactions with LCZ696 and spironolactone on cardiac fibroblasts of patients with heart failure and reduced ejection fraction
Ortega-Paz L, Cristobal H, Ortiz-Perez J, Garcia de Frutos P, Mendieta G, Sandoval E, et al.
ESC Heart Fail . 2022 Oct; 10(1):453-464. PMID: 36303443
Aims: Inhibitors of SGLT2 (SGLT2i) have shown a positive impact in patients with chronic heart failure and reduced ejection fraction (HFrEF). Nonetheless, the direct effects of SGLT2i on cardiac cells...
3.
Soluble AXL is a novel blood marker for early detection of pancreatic ductal adenocarcinoma and differential diagnosis from chronic pancreatitis
Martinez-Bosch N, Cristobal H, Iglesias M, Gironella M, Barranco L, Visa L, et al.
EBioMedicine . 2022 Jan; 75:103797. PMID: 34973624
Background: Early diagnosis is crucial for patients with pancreatic ductal adenocarcinoma (PDAC). The AXL receptor tyrosine kinase is proteolytically processed releasing a soluble form (sAXL) into the blood stream. Here...
4.
Growth Arrest-Specific Factor 6 (GAS6) Is Increased in COVID-19 Patients and Predicts Clinical Outcome
Morales A, Rojo Rello S, Cristobal H, Fiz-Lopez A, Arribas E, Mari M, et al.
Biomedicines . 2021 Apr; 9(4). PMID: 33810394
Background: Growth arrest-specific factor 6 (GAS6) and the Tyro3, AXL, and MERTK (TAM) receptors counterbalance pro-inflammatory responses. AXL is a candidate receptor for SARS-CoV-2, particularly in the respiratory system, and...
5.
A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target
Tutusaus A, de Gregorio E, Cucarull B, Cristobal H, Areste C, Graupera I, et al.
Cell Mol Gastroenterol Hepatol . 2019 Nov; 9(3):349-368. PMID: 31689560
Background And Aims: GAS6 signaling, through the TAM receptor tyrosine kinases AXL and MERTK, participates in chronic liver pathologies. Here, we addressed GAS6/TAM involvement in Non-Alcoholic SteatoHepatitis (NASH) development. Methods:...
6.
Axl expression is increased in early stages of left ventricular remodeling in an animal model with pressure-overload
Batlle M, Castillo N, Alcarraz A, Sarvari S, Sanguesa G, Cristobal H, et al.
PLoS One . 2019 Jun; 14(6):e0217926. PMID: 31181097
Background: AXL is a receptor tyrosine kinase that has been related to kidney and vascular disorders. Heart failure patients with reduced ejection fraction have higher AXL in serum than controls....
7.
Serum levels of Growth Arrest-Specific 6 protein and soluble AXL in patients with ST-segment elevation myocardial infarction
Caldentey G, Garcia de Frutos P, Cristobal H, Garabito M, Berruezo A, Bosch X, et al.
Eur Heart J Acute Cardiovasc Care . 2017 Nov; 8(8):708-716. PMID: 29119801
Background: Serum soluble AXL (sAXL) and its ligand, Growth Arrest-Specific 6 protein (GAS6), intervene in tissue repair processes. AXL is increased in end-stage heart failure, but the role of GAS6...