Helcio Silva Dos Santos
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Explore the profile of Helcio Silva Dos Santos including associated specialties, affiliations and a list of published articles.
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92
Citations
215
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Recent Articles
1.
Lopes P, Pereira N, da Rocha M, Marinho M, Guedes J, Rodrigues T, et al.
Molecules
. 2025 Mar;
30(5).
PMID: 40076259
The mosquito is the primary vector of dengue, a neglected disease and a serious public health problem in tropical countries. The control of this vector has been carried out using...
2.
Lima Mendes J, Everson da Silva L, do Amaral W, Confortin C, Kueirislene Amancio Ferreira M, Marinho M, et al.
Chem Biodivers
. 2025 Mar;
:e202403357.
PMID: 40044596
Benzodiazepines are medications used to treat anxiety and epilepsy disorders. However, because of the existing adverse effects, new and safer medications are being sought. Therefore, this study aims to evaluate...
3.
Mishra R, da Cunha Xavier J, Kumar N, Krishna G, Dhakad P, Santos H, et al.
Med Chem
. 2025 Feb;
21(2):96-121.
PMID: 40007183
Objectives: Malaria continues to be the primary cause of mortality worldwide, and timely recognition and prompt intervention are crucial in mitigating adverse consequences. This review article aims to examine the...
4.
de Sousa Silveira Z, Silva Macedo N, Menezes Dantas D, Rodrigues Dos Santos Barbosa C, Muniz D, Datiane de Morais Oliveira-Tintino C, et al.
Microb Pathog
. 2025 Jan;
200:107318.
PMID: 39848298
The NorA and TetK efflux pumps mediate resistance to fluoroquinolone and tetracycline antibiotics by actively extruding these compounds and reducing their intracellular concentrations. Consequently, intense research has focused on inhibiting...
5.
Freitas P, Araujo A, Araujo I, Almeida R, Oliveira Borges J, Lima C, et al.
Biochimie
. 2024 Dec;
231:104-109.
PMID: 39708974
Thiadiazines are heterocyclic compounds known for some pharmacological activities. However, the ability of these compounds and their derivatives to act as antibacterial agents and inhibitors of the efflux system in...
6.
Ali A, de Almeida I, Paula Magalhaes E, Guedes J, Mesquita Cajazeiras F, Marinho M, et al.
Biol Chem
. 2024 Dec;
405(11-12):727-743.
PMID: 39705087
Ischemia/reperfusion injury (I/R) is a leading cause of acute kidney injury (AKI) in conditions like kidney transplants, cardiac surgeries, and nephrectomy, contributing to high global mortality and morbidity. This study...
7.
da Silva B, Pereira A, Frota Araujo I, Carvalho Aguiar F, Mesquita Cajazeiras F, Onassis Cardoso Viana Gomes A, et al.
Microb Pathog
. 2024 Dec;
199():107230.
PMID: 39689746
The study investigates the synthesis, characterization, and antibacterial activity of an ibuprofen-derived hydrazide (HIDZ). It was synthesized and characterized using NMR spectroscopy, DFT Calculations, and ADMET studies. Furthermore, HIDZ cytotoxicity...
8.
Guimaraes Lemos C, Wlisses da Silva A, Bezerra Maciel J, Kueirislene Amancio Ferreira M, da Rocha M, Marinho M, et al.
Chem Biodivers
. 2024 Dec;
:e202402173.
PMID: 39660673
This study investigated the anxiolytic, anticonvulsant and memory preservation effects of the flavonoid robinin. The compound, administered at doses of 4, 20 and 40 mg/kg, did not show toxicity after...
9.
da Costa R, Torres Pessoa R, Dos Santos Silva E, Araujo I, Goncalves S, Rocha J, et al.
Pharmaceutics
. 2024 Nov;
16(11).
PMID: 39598592
The work investigates the effect of the estragole complex encapsulated in beta-cyclodextrin (ES/β-CD) in modulating bacterial resistance, specifically in strains expressing NorA and MepA efflux pumps. Efflux pumps are mechanisms...
10.
Nascimento J, Silva Abreu F, Holanda T, Oliveira Dos Santos Fontenelle R, Prado J, Marinho E, et al.
Pharmaceuticals (Basel)
. 2024 Nov;
17(11).
PMID: 39598354
Nanoemulsions (NEs) possess properties that enhance the solubility, bioavailability and therapeutic efficacy of drugs. Chalcones are compounds known for their antifungal properties. In this study, we evaluated different emulsification techniques...