Heiko Sic
Overview
Explore the profile of Heiko Sic including associated specialties, affiliations and a list of published articles.
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12
Citations
376
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Recent Articles
1.
Sic H, Speletas M, Cornacchione V, Seidl M, Beibel M, Linghu B, et al.
Front Immunol
. 2018 Jan;
8:1824.
PMID: 29375547
Heterozygous mutations in the cytotoxic T lymphocyte antigen-4 (CTLA-4) are associated with lymphadenopathy, autoimmunity, immune dysregulation, and hypogammaglobulinemia in about 70% of the carriers. So far, the incomplete penetrance of...
2.
Marrella V, Lo Iacono N, Fontana E, Sobacchi C, Sic H, Schena F, et al.
J Immunol
. 2015 Apr;
194(9):4144-53.
PMID: 25825446
The immune and the skeletal system are tightly interconnected, and B lymphocytes are uniquely endowed with osteo-interactive properties. In this context, receptor activator of NF-κB (RANK) ligand (RANKL) plays a...
3.
Bornancin F, Renner F, Touil R, Sic H, Kolb Y, Touil-Allaoui I, et al.
J Immunol
. 2015 Mar;
194(8):3723-34.
PMID: 25762782
The paracaspase MALT1 plays an important role in immune receptor-driven signaling pathways leading to NF-κB activation. MALT1 promotes signaling by acting as a scaffold, recruiting downstream signaling proteins, as well...
4.
Xu H, Huang J, Khairnar V, Duhan V, Pandyra A, Grusdat M, et al.
J Virol
. 2015 Feb;
89(9):4748-59.
PMID: 25673724
Unlabelled: The B cell-activating factor (BAFF) is critical for B cell development and humoral immunity in mice and humans. While the role of BAFF in B cells has been widely...
5.
Willmann K, Klaver S, Dogu F, Santos-Valente E, Garncarz W, Bilic I, et al.
Nat Commun
. 2014 Nov;
5:5360.
PMID: 25406581
Primary immunodeficiency disorders enable identification of genes with crucial roles in the human immune system. Here we study patients suffering from recurrent bacterial, viral and Cryptosporidium infections, and identify a...
6.
Rakhmanov M, Sic H, Kienzler A, Fischer B, Rizzi M, Seidl M, et al.
PLoS One
. 2014 Jun;
9(6):e100328.
PMID: 24945754
Currently very little is known about the differential expression and function of the transcription factor SOX5 during B cell maturation. We identified two new splice variants of SOX5 in human...
7.
Salzer E, Kansu A, Sic H, Majek P, Ikinciogullari A, Dogu F, et al.
J Allergy Clin Immunol
. 2014 Apr;
133(6):1651-9.e12.
PMID: 24746753
Background: Alterations of immune homeostasis in the gut can result in development of inflammatory bowel disease (IBD). Recently, Mendelian forms of IBD have been discovered, as exemplified by deficiency of...
8.
Sic H, Kraus H, Madl J, Flittner K, von Munchow A, Pieper K, et al.
J Allergy Clin Immunol
. 2014 Apr;
134(2):420-8.
PMID: 24679343
Background: Five different G protein-coupled sphingosine-1-phosphate (S1P) receptors (S1P1-S1P5) regulate a variety of physiologic and pathophysiologic processes, including lymphocyte circulation, multiple sclerosis (MS), and cancer. Although B-lymphocyte circulation plays an...
9.
Eibel H, Kraus H, Sic H, Kienzler A, Rizzi M
Curr Allergy Asthma Rep
. 2014 Mar;
14(5):434.
PMID: 24633618
In this review we summarize recent insights into the development of human B cells primarily by studying immunodeficiencies. Development and differentiation of B cells can be considered as a paradigm...
10.
Pieper K, Rizzi M, Speletas M, Smulski C, Sic H, Kraus H, et al.
J Allergy Clin Immunol
. 2014 Jan;
133(4):1222-5.
PMID: 24406071
No abstract available.