Heike Grassme
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Explore the profile of Heike Grassme including associated specialties, affiliations and a list of published articles.
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52
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1859
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Recent Articles
1.
Grassme H, Wilson G, Wu Y, Hasenberg M, Keitsch S, Caicci F, et al.
Infect Immun
. 2025 Mar;
:e0059124.
PMID: 40062881
Respiratory infections with multiresistant are a major clinical problem, affecting mainly patients with pre-existing lung diseases such as cystic fibrosis (CF) or chronic obstructive pulmonary disease but also immunocompromised or...
2.
May H, Liu Y, Kadow S, Edwards M, Keitsch S, Wilker B, et al.
Pathog Dis
. 2024 Jul;
82.
PMID: 39030066
Sphingosine has been previously shown to kill many strains of pathogenic bacteria including Pseudomonas aeruginosa, Staphyloccus aureus, Acinetobacter, and atypical mycobacteria. However, these studies were performed on isolated or extracellular...
3.
Wu Y, Riehle A, Pollmeier B, Kadow S, Schumacher F, Drab M, et al.
Tuberculosis (Edinb)
. 2024 Mar;
147:102493.
PMID: 38547568
Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the deadliest infections in humans. Because Mycobacterium bovis Bacillus Calmette-Guérin (BCG) share genetic similarities with Mycobacterium tuberculosis, it is often used as...
4.
Schnitker F, Liu Y, Keitsch S, Soddemann M, Verhasselt H, Kehrmann J, et al.
Int J Mol Sci
. 2023 Sep;
24(18).
PMID: 37762308
Cystic fibrosis (CF) is an autosomal recessive disorder caused by the deficiency of the cystic fibrosis transmembrane conductance regulator (CFTR) and often leads to pulmonary infections caused by various pathogens,...
5.
Wu Y, Liu Y, Gulbins E, Grassme H
Cells
. 2021 Jun;
10(5).
PMID: 34064516
Sphingolipids are important structural membrane components and, together with cholesterol, are often organized in lipid rafts, where they act as signaling molecules in many cellular functions. They play crucial roles...
6.
Wu Y, Li C, Peng H, Swaidan A, Riehle A, Pollmeier B, et al.
Cells
. 2020 Nov;
9(11).
PMID: 33153072
Tuberculosis, caused by , is one of the most severe diseases worldwide. The initial pulmonary localization of the pathogen often develops into systemic infection with high lethality. The present work...
7.
Li C, Wang A, Wu Y, Gulbins E, Grassme H, Zhao Z
Cell Physiol Biochem
. 2019 Mar;
52(2):280-301.
PMID: 30816675
Acid sphingomyelinase hydrolyzes sphingomyelin to ceramide and phosphorylcholine. Ceramide molecules spontaneously interact with each other and generate ceramide-enriched membrane domains. These ceramide-enriched domains further fuse, forming large ceramideenriched platforms that...
8.
Wu Y, Li C, Riehle A, Pollmeier B, Gulbins E, Grassme H
Cell Physiol Biochem
. 2018 Dec;
51(4):1815-1829.
PMID: 30504725
Background/aims: Mycobacteria-induced diseases, especially tuberculosis, cause more than 1 million deaths each year, which is higher than any other single bacterial pathogen. Neutral sphingomyelinase 2 (Nsm2) has been implied in...
9.
Wu Y, Gulbins E, Grassme H
Biol Chem
. 2018 Jun;
399(10):1125-1133.
PMID: 29924725
Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the deadliest and most important infectious diseases worldwide. The sphingomyelinase/ceramide system, which has been shown several times to be a crucial...
10.
Becker K, Riethmuller J, Seitz A, Gardner A, Boudreau R, Kamler M, et al.
Adv Drug Deliv Rev
. 2018 Apr;
133:66-75.
PMID: 29698625
Studies over the past several years have demonstrated the important role of sphingolipids in cystic fibrosis (CF), chronic obstructive pulmonary disease and acute lung injury. Ceramide is increased in airway...